BTCP HCl
BTCP HCl structure
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Common Name | BTCP HCl | ||
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| CAS Number | 112726-66-6 | Molecular Weight | 299.474 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 425.4±20.0 °C at 760 mmHg | |
| Molecular Formula | C19H25NS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 211.1±21.8 °C | |
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Studies of the biogenic amine transporters. III. Demonstration of two binding sites for [3H]GBR12935 and [3H]BTCP in rat caudate membranes.
J. Pharmacol. Exp. Ther. 268 , 1462-1475, (1994) The present study addressed the hypothesis that there exist multiple sites/states associated with the dopamine (DA) transporter ligands. The authors used [3H](1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine) (GBR12935) and [3H]-N-(1-(2-benzo[b]thiop... |
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Developmentally regulated glycosylation of dopamine transporter.
Brain Res. Dev. Brain Res. 83(1) , 53-8, (1994) The dopamine transporter (DAT) in rat striatum was examined during postnatal development and aging after photolabeling with [125I]DEEP. The DAT-[125I]DEEP protein complex from adult rats (2 months) appeared as a broad diffuse band in SDS-PAGE gels with averag... |
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MK-801, phencyclidine (PCP), and PCP-like drugs increase burst firing in rat A10 dopamine neurons: comparison to competitive NMDA antagonists.
Synapse 13(2) , 108-16, (1993) Extracellular single-unit recordings were used to assess the effects of PCP and PCP-like drugs (MK-801 and TCP) on the burst firing of ventral tegmental A10 dopamine neurons in the rat. The effects of these noncompetitive N-methyl-D-aspartate (NMDA) receptor ... |
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N-[1-(2-benzo[b]thiophenyl)Cyclohexyl]- piperidine (BTCP) exerts cocaine-like actions on drug-maintained responding in rats.
Biol. Psychiatry 23(3) , 316-25, (2000) The effects of N-[1-(2-benzo[b]thiophenyl)cyclohexyl]- piperidine (BTCP), a phencyclidine derivative that acts as a potent dopamine reuptake inhibitor, were examined on cocaine self-administration in rats. The effects of BTCP (0, 4, 8, 16, and 32 mg/kg, i.p.)... |
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Thermodynamics of the binding of BTCP (GK 13) and related derivatives on the dopamine neuronal carrier.
Eur. J. Pharmacol. 268(3) , 357-63, (1994) We have studied the thermodynamic properties of the binding of a coherent series of uptake inhibitors derived from BTCP (GK 13 = N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine) to the dopamine neuronal carrier labelled with [3H]GBR 12783 (1-[2-(diphenylmeth... |
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Alterations in the dopaminergic receptor system after chronic administration of cocaine.
Synapse 14(4) , 314-23, (1993) Several studies suggest that one of the most important factors contributing to cocaine dependence is an alteration in the actions of the neurotransmitter dopamine in the central nervous system. In order to understand some of the neuroreceptor consequences of ... |
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Conformational preferences of the potent dopamine reuptake blocker BTCP and its analogs and their incorporation into a pharmacophore model.
J. Comput. Aided Mol. Des. 14(2) , 135-46, (2000) Molecular mechanics calculations using MM3-92 and ab initio quantum mechanical calculations using SPARTAN 5.0 were performed on the structurally similar PCP and BTCP, in which only the latter has a cocaine-like pharmacological profile as a dopamine reuptake b... |
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1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) yields two active primary metabolites in vivo. Identification and quantification of BTCP primary metabolites in mice plasma, urine, and brain and their affinity for the neuronal dopamine transporter.
Eur. J. Pharm. Sci. 9(4) , 345-54, (2000) 1-[1-(2-Benzo[b]thiopheneyl)cyclohexyl]piperidine hydrochloride (BTCP) and cocaine bind to the neuronal dopamine transporter (DAT) to strongly inhibit dopamine (DA) reuptake. Although similar to acute administration, cocaine and BTCP produce sensitization and... |
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Synthesis and biodistribution of two potential PET radioligands for dopamine reuptake sites: no-carrier-added 4-(2-[18F]fluoroethyl) and 4-[11C]methyl BTCP-piperazine.
Nucl. Med. Biol. 24(6) , 513-8, (1997) Radioligands that specifically target dopamine uptake sites can provide a means of determining dopamine fiber loss at intrastriatal mesencephalic grafts in Parkinsonian patients, using Positron Emission Tomography (PET). The BTCP derivative, 1-[1-(2-benzo(b)t... |
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Non reciprocal cross-sensitization between cocaine and BTCP on locomotor activity in the rat.
Pharmacol. Biochem. Behav. 66(3) , 631-5, (2000) Measurement of locomotor sensitization was employed to characterize the effect of intermittent treatment with N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) and cocaine in the rat. Like cocaine, BTCP possesses high affinity for the dopamine transport... |