thiophene-3-carboxamide

thiophene-3-carboxamide Structure
thiophene-3-carboxamide structure
Common Name thiophene-3-carboxamide
CAS Number 51460-47-0 Molecular Weight 127.16400
Density 1.302g/cm3 Boiling Point 313.5ºC at 760 mmHg
Molecular Formula C5H5NOS Melting Point 181-184ºC(lit.)
MSDS Chinese USA Flash Point 143.4ºC

p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα.

J. Cell. Mol. Med. 20 , 58-70, (2016)

Cullin-RING-ubiquitin-ligase (CRL)-dependent ubiquitination of the nuclear factor kappa B (NF-κB) inhibitor IκBα and its subsequent degradation by the proteasome usually precede NF-κB/RelA nuclear activity. Through removal of the CRL-activating modification o...