3'-P-HYDROXY PACLITAXEL
3'-P-HYDROXY PACLITAXEL structure
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Common Name | 3'-P-HYDROXY PACLITAXEL | ||
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| CAS Number | 132160-32-8 | Molecular Weight | 869.90600 | |
| Density | 1.43g/cm3 | Boiling Point | 988.2ºC at 760mmHg | |
| Molecular Formula | C47H51NO15 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 551.4ºC | |
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Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography.
J. Chromatogr. B, Biomed. Appl. 674(2) , 261-8, (1995) A reversed-phase high-performance liquid chromatographic (HPLC) method has been validated for the quantitative determination of the three major paclitaxel metabolites (6 alpha-hydroxypaclitaxel, 3'-p-hydroxypaclitaxel, 6 alpha,3'-p-dihydroxypaclitaxel) in hum... |
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Human liver microsomal metabolism of paclitaxel and drug interactions.
Eur. J. Drug Metab. Pharmacokinet. 23 , 417, (1998) The aim of this study was to investigate the influence of several anticancer drugs and investigational multidrug resistance (MDR) reversing agents on the hepatic metabolism of paclitaxel (Taxol) to its primary metabolites, 6alpha-hydroxypaclitaxel (metabolite... |
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Quantitative determination of paclitaxel and its metabolites, 6α-hydroxypaclitaxel and p-3'-hydroxypaclitaxel, in human plasma using column-switching liquid chromatography/tandem mass spectrometry.
Biomed. Chromatogr. 27(4) , 539-44, (2013) A column-switching liquid chromatography/electrospray ionization tandem mass spectrometry to determine paclitaxel and its metabolites, 6α-hydroxypaclitaxel and p-3'-hydroxypaclitaxel, in human plasma was developed. The analytical system had a Shim-Pack MAYI-O... |
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Measurement of paclitaxel and its metabolites in human plasma using liquid chromatography/ion trap mass spectrometry with a sonic spray ionization interface.
Rapid Commun. Mass Spectrom. 20(14) , 2183-9, (2006) A quantitative liquid chromatography/ion trap mass spectrometry method for the simultaneous determination of paclitaxel, 6alpha-hydroxypaclitaxel and p-3'-hydroxypaclitaxel in human plasma has been developed and validated. 6alpha-,p-3'-Dihydroxypaclitaxel was... |
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Quantitation of paclitaxel and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(22) , 2018-22, (2011) A sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method for the determination of paclitaxel (Taxol) and its two major metabolites in human plasma has been developed. Samples were prepared after liquid-liquid extraction and... |
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Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4.
J. Pharmacol. Sci. 97(1) , 83-90, (2005) Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified. Recent progress in pharmacogenetics has shown... |