Desmesterol
Desmesterol structure
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Common Name | Desmesterol | ||
|---|---|---|---|---|
| CAS Number | 313-04-2 | Molecular Weight | 384.638 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 483.2±14.0 °C at 760 mmHg | |
| Molecular Formula | C27H44O | Melting Point | 121.5ºC | |
| MSDS | Chinese USA | Flash Point | 209.2±12.4 °C | |
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A liquid chromatography-tandem mass spectrometry-based method for the simultaneous determination of hydroxy sterols and bile acids.
J. Chromatogr. A. 1371 , 184-95, (2014) Recently, hydroxy sterols and bile acids have gained growing interest as they are important regulators of energy homoeostasis and inflammation. The high number of different hydroxy sterols and bile acid species requires powerful analytical tools to quantify t... |
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Sterol Composition in Infant Formulas and Estimated Intake.
J. Agric. Food Chem. 63 , 7245-51, (2015) Sterol contents in infant formulas (IFs) from the European market were determined, and their intakes by infants between 0 and 6 months were evaluated. Total animal sterols (mg/100 mL) ranged from 1.71 to 5.46, cholesterol being the main animal sterol (1.46-5.... |
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Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.
Hum. Mol. Genet. 24 , 2808-25, (2015) NSDHL is a 3β-hydroxysterol dehydrogenase that is involved in the removal of two C-4 methyl groups in one of the later steps of cholesterol biosynthesis. Mutations in the gene encoding the enzyme are responsible for the X-linked, male lethal mouse mutations b... |
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The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers.
PLoS ONE 9(12) , e115663, (2014) Cytoplasmic constitutive active/androstane receptor (CAR) retention protein (CCRP and also known as DNAJC7) is a co-chaperone previously characterized to retain nuclear receptor CAR in the cytoplasm of HepG2 cells. Here we have produced CCRP knockout (KO) mic... |
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Plumbagin elicits differential proteomic responses mainly involving cell cycle, apoptosis, autophagy, and epithelial-to-mesenchymal transition pathways in human prostate cancer PC-3 and DU145 cells.
Drug Des. Devel. Ther. 9 , 349-417, (2015) Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare the quantitative proteomic responses to PLB treatment in human prostate cancer PC-3 and DU145 cells usi... |
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Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.
J. Chromatogr. A. 1364 , 214-22, (2014) We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of several oxysterols and vitamin D metabolites in mouse brai... |
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Lipidomics reveals a remarkable diversity of lipids in human plasma.
J. Lipid Res. 51(11) , 3299-305, (2010) The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians r... |
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Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment.
J. Lipid Res. 30(12) , 1953-62, (1989) We have studied the effect of ursodeoxycholic acid on the serum and urinary bile acids in seven patients with moderate to severe primary biliary cirrhosis. Bile acids were characterized by gas-liquid chromatography-mass spectrometry and quantified by capillar... |
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Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1.
J. Lipid Res. 55(9) , 1933-43, (2014) Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,27-dihydr... |
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The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity.
Nat. Commun. 6 , 6354, (2015) ATP-binding cassette transporter G1 (ABCG1) promotes cholesterol efflux from cells and regulates intracellular cholesterol homeostasis. Here we demonstrate a role of ABCG1 as a mediator of tumour immunity. Abcg1(-/-) mice have dramatically suppressed subcutan... |