Zinquin
Zinquin structure
|
Common Name | Zinquin | ||
|---|---|---|---|---|
| CAS Number | 151606-29-0 | Molecular Weight | 386.42 | |
| Density | 1.412g/cm3 | Boiling Point | 608ºC at 760 mmHg | |
| Molecular Formula | C19H18N2O5S | Melting Point | 112-114ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
|
Vimentin filament organization and stress sensing depend on its single cysteine residue and zinc binding.
Nat. Commun. 6 , 7287, (2015) The vimentin filament network plays a key role in cell architecture and signalling, as well as in epithelial-mesenchymal transition. Vimentin C328 is targeted by various oxidative modifications, but its role in vimentin organization is not known. Here we show... |
|
|
Sensor specific imaging of proteomic Zn2+ with zinquin and TSQ after cellular exposure to N-ethylmaleimide.
Metallomics 4(5) , 448-56, (2012) The impact of the thiol binding reagent N-ethylmaleimide (NEM) on proteomic Zn(2+) availability was investigated in rat glioma cells. Zinquin (ZQ) or TSQ, two related fluorescent sensors, were used to observe reactive Zn(2+). Control cells contained proteomic... |
|
|
3,3'-Dihydroxyisorenieratene prevents UV-induced formation of reactive oxygen species and the release of protein-bound zinc ions in human skin fibroblasts.
Mol. Nutr. Food. Res. 54(2) , 285-91, (2010) 3,3'-Dihydroxyisorenieratene (DHIR) is a structurally unusual carotenoid exhibiting bifunctional antioxidant properties. It is synthesized by Brevibacterium linens, used in dairy industry for the production of red smear cheeses. The compound protects cellular... |
|
|
Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion.
PLoS ONE 4(5) , e5679, (2009) The SLC30A8 gene codes for a pancreatic beta-cell-expressed zinc transporter, ZnT8. A polymorphism in the SLC30A8 gene is associated with susceptibility to type 2 diabetes, although the molecular mechanism through which this phenotype is manifest is incomplet... |
|
|
The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.
Mol. Biol. Cell 15(2) , 575-87, (2004) Synaptic vesicles (SV) are generated by two different mechanisms, one AP-2 dependent and one AP-3 dependent. It has been uncertain, however, whether these mechanisms generate SV that differ in molecular composition. We explored this hypothesis by analyzing th... |
|
|
Fluctuations of cellular, available zinc modulate insulin signaling via inhibition of protein tyrosine phosphatases.
J. Trace Elem. Med. Biol. 19(1) , 37-42, (2005) Extracellular zinc ions are effectors of many signaling pathways in mammalian cells, including the insulin/IGF-1 pathway. Molecular targets of zinc are intracellular, however, because otherwise ineffective zinc concentrations alter the extent of protein phosp... |
|
|
Apoptosis may underlie the pathology of zinc-deficient skin.
Immunol. Cell Biol. 84(1) , 28-37, (2006) The trace element zinc is essential for the survival and function of all cells. Zinc deficiency, whether nutritional or genetic, is fatal if left untreated. The effects of zinc deficiency are particularly obvious in the skin, seen as an erythematous rash, sca... |
|
|
Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.
Cancer Biol. Ther. 12(4) , 297-303, (2011) Pancreatic adenocarcinoma is an untreatable deadly cancer. The factors involved in its early development remain unknown; which contributes to the absence of biomarkers for early detection of malignancy or at-risk subjects, and the absence of efficacious thera... |
|
|
Zinquin identifies subcellular compartmentalization of zinc in cortical neurons. Relation to the trafficking of zinc and the mitochondrial compartment.
Brain Res. 1085(1) , 1-10, (2006) Zinquin (Zn(2+) selective fluorophore), when used to visualize intracellular Zn(2+), typically shows brightly fluorescent perinuclear endosome-like structures, presumably identifying Zn(2+) containing organelles. In this study, zinquin identified numerous and... |
|
|
S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils.
Int. J. Biochem. Cell Biol. 37(6) , 1241-53, (2005) The two calcium- and zinc-binding proteins, S100A9 and S100 A8, abundant in myeloid cells are considered to play important roles in both calcium signalling and zinc homeostasis. Polymorphonuclear neutrophils from S100A9 ko mice are also devoid of S100A8. Ther... |