NG,NG-Dimethylarginine Dihydrochloride
NG,NG-Dimethylarginine Dihydrochloride structure
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Common Name | NG,NG-Dimethylarginine Dihydrochloride | ||
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| CAS Number | 220805-22-1 | Molecular Weight | 275.18 | |
| Density | N/A | Boiling Point | 427.5ºC at 760 mmHg | |
| Molecular Formula | C8H20Cl2N4O2 | Melting Point | 202-204OºC | |
| MSDS | Chinese USA | Flash Point | 212.4ºC | |
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Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2.
J. Biol. Chem. 290 , 16723-43, (2015) Human protein arginine methyltransferase (PRMT) 9 symmetrically dimethylates arginine residues on splicing factor SF3B2 (SAP145) and has been functionally linked to the regulation of alternative splicing of pre-mRNA. Site-directed mutagenesis studies on this ... |
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PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.
Nat. Commun. 6 , 6428, (2015) The human genome encodes a family of nine protein arginine methyltransferases (PRMT1-9), whose members can catalyse three distinct types of methylation on arginine residues. Here we identify two spliceosome-associated proteins-SAP145 and SAP49-as PRMT9-bindin... |
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Effects of nitric oxide synthase deficiency on a disintegrin and metalloproteinase domain-containing protein 12 expression in mouse brain samples.
Mol. Med. Report. 12 , 2253-62, (2015) A disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) belongs to the ADAM family of transmembrane proteins. Via proteolysis, cell adhesion, cell-cell fusion, cell-matrix interaction and membrane protein shedding, ADAM proteins are involved... |
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Organic anion transporting polypeptides 1B1 and 1B3 play an important role in uremic toxin handling and drug-uremic toxin interactions in the liver.
J. Pharm. Pharm. Sci. 17(4) , 475-84, (2015) Organic anion-transporting polypeptide (OATP) 1B1 and OATP1B3 contribute to hepatic uptake of numerous drugs. Thus, reduced OATP1B1 and OATP1B3 activity in chronic kidney disease (CKD) may have a major impact on the hepatic clearance of drugs. The effect of d... |
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Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats.
Hepatology 59(6) , 2286-98, (2014) The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. We studied the effect of short-term treatment with obeticholic acid (INT-747), a... |
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Digital plethysmography and arginine metabolism in prehypertension: effect of nebivolol therapy.
J. Clin. Hypertens. (Greenwich.) 17(1) , 14-9, (2015) Prehypertension is an important phenotype for cardiovascular risk and development of established hypertension. To better understand the early circulatory changes in this group, the authors studied 34 patients with prehypertension (blood pressure 120-139/80-89... |
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Statin-induced inhibition of breast cancer proliferation and invasion involves attenuation of iron transport: intermediacy of nitric oxide and antioxidant defence mechanisms.
FEBS J. 281(16) , 3719-38, (2014) Accumulating evidence from in vitro, in vivo, clinical and epidemiological studies shows promising results for the use of statins against many cancers including breast carcinoma. However, the molecular mechanisms responsible for the anti-proliferative and ant... |
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Serelaxin reduces oxidative stress and asymmetric dimethylarginine in angiotensin II-induced hypertension.
Am. J. Physiol. Renal Physiol. 307(12) , F1355-62, (2014) Recent findings suggest the therapeutic action of relaxin during hypertension is dependent on nitric oxide synthase (NOS) activation; however, the mechanisms underlying the beneficial effects of relaxin on the NOS system have not been fully elucidated. We hyp... |
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Probucol Protects Against Asymmetric Dimethylarginine-Induced Apoptosis in the Cultured Human Brain Microvascular Endothelial Cells.
J. Mol. Neurosci. 57 , 546-53, (2015) Asymmetric dimethylarginine (ADMA) is emerging as a key contributor to endothelial dysfunction. The drug probucol was reported to have an anti-lipid peroxidation effect and improve endothelial dilation function. But little is known about the protective effect... |
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Large-Scale Computations in Chemistry: A Bird's Eye View of a Vibrant Field.
Chem. Rev. 115 , 5797-890, (2015)
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