DL-Threo-beta-Hydroxyaspartic Acid
DL-Threo-beta-Hydroxyaspartic Acid structure
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Common Name | DL-Threo-beta-Hydroxyaspartic Acid | ||
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| CAS Number | 4294-45-5 | Molecular Weight | 149.10200 | |
| Density | 1.738 g/cm3 | Boiling Point | 368.7ºC at 760 mmHg | |
| Molecular Formula | C4H7NO5 | Melting Point | >230ºC dec | |
| MSDS | Chinese USA | Flash Point | 176.8ºC | |
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The SLC1 high-affinity glutamate and neutral amino acid transporter family.
Mol. Aspects Med. 34(2-3) , 108-20, (2013) Glutamate transporters play important roles in the termination of excitatory neurotransmission and in providing cells throughout the body with glutamate for metabolic purposes. The high-affinity glutamate transporters EAAC1 (SLC1A1), GLT1 (SLC1A2), GLAST (SLC... |
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A concise, asymmetric synthesis of (2R,3R)-3-hydroxyaspartic acid.
Amino Acids 35(2) , 507-10, (2008) 3-Hydroxyaspartic acid and its derivatives are found both in the free form and as peptide constituents in various microorganisms and fungi. Considering the biological importance of this amino acid and its potential utility as a multifunctional building block ... |
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Insights into the mechanism of Pseudomonas dacunhae aspartate beta-decarboxylase from rapid-scanning stopped-flow kinetics.
Biochemistry 49 , 5066-73, (2010) The mechanism of wild-type and R37A mutant Pseudomonas dacunhae aspartate beta-decarboxylase (ABDC) was studied by rapid-scanning stopped-flow spectrophotometry. Mixing wild-type ABDC with 50 mM disodium l-Asp resulted in the formation of a 325 nm absorption ... |
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Neuroprotective effects of yokukansan, a traditional Japanese medicine, on glutamate-mediated excitotoxicity in cultured cells.
Neuroscience 159(4) , 1397-407, (2009) To clarify the mechanism of yokukansan (TJ-54), a traditional Japanese medicine, against glutamate-mediated excitotoxicity, the effects of TJ-54 on glutamate uptake function were first examined using cultured rat cortical astrocytes. Under thiamine-deficient ... |
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Serine racemase homologue of Saccharomyces cerevisiae has L-threo-3-hydroxyaspartate dehydratase activity.
FEMS Microbiol. Lett. 225(2) , 189-93, (2003) The NH(2)-terminal amino acid sequence of L-threo-3-hydroxyaspartate dehydratase from Pseudomonas sp. T62 showed significant similarity to that of the SRY1 gene product of Saccharomyces cerevisiae (serine racemase in yeast). SRY1 was cloned and expressed in E... |
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Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid.
ChemBioChem. 9(3) , 374-6, (2008)
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Expression of GFP-tagged neuronal glutamate transporters in cerebellar Purkinje neurons.
Neuropharmacology 49(6) , 883-9, (2005) Of the five excitatory amino acid transporters (EAATs) identified, two genes are expressed by neurons (EAAT3 and EAAT4) and give rise to transporters confined to neuronal cell bodies and dendrites. At an ultrastructural level, EAAT3 and EAAT4 proteins are clu... |
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A practical synthesis of N α-Fmoc protected L-threo-β-hydroxyaspartic acid derivatives for coupling via α- or β-carboxylic group.
Amino Acids 42(1) , 285-93, (2012) A simple and practical general synthetic protocol towards orthogonally protected tHyAsp derivatives fully compatible with Fmoc solid-phase peptide synthetic methodology is reported. Our approach includes enantioresolution of commercially available D: ,L: -tHy... |
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Identification of glutamate transporters and receptors in mouse testis.
Acta Pharmacol. Sin. 25(3) , 366-71, (2004) To investigate the presence of glutamate transporters and receptors in mouse testis.Glutamate uptake analysis was performed to study the function of glutamate transporters in mouse testis. Comparative RT-PCR technique and sequencing analysis were used to stud... |
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Iron is a potential key mediator of glutamate excitotoxicity in spinal cord motor neurons.
Brain Res. 1257 , 102-7, (2009) Threohydroxyaspartate (THA)-induced glutamate excitotoxicity in organotypic culture of rat spinal cord is a well-known model of motor neuron degeneration. THA causes accumulation of synaptic glutamate and over stimulation of the postsynaptic receptor by inhib... |