Parthenolide
Parthenolide structure
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Common Name | Parthenolide | ||
|---|---|---|---|---|
| CAS Number | 20554-84-1 | Molecular Weight | 248.318 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 394.1±42.0 °C at 760 mmHg | |
| Molecular Formula | C15H20O3 | Melting Point | 115-116ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 166.3±22.5 °C | |
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Distinct phenotypes of human prostate cancer cells associate with different adaptation to hypoxia and pro-inflammatory gene expression.
PLoS ONE 9(5) , e96250, (2014) Hypoxia and inflammation are strictly interconnected both concurring to prostate cancer progression. Numerous reports highlight the role of tumor cells in the synthesis of pro-inflammatory molecules and show that hypoxia can modulate a number of these genes c... |
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Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.
J. Chromatogr. A. 1385 , 103-10, (2015) The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical as a post-chromatographic derivatization agent to compare ... |
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Secoiridoid glycosides from the root of Gentiana crassicaulis with inhibitory effects against LPS-induced NO and IL-6 production in RAW264 macrophages.
J. Nat. Med. 69 , 366-74, (2015) The root of Gentiana crassicaulis has been widely used for the treatment of rheumatism, arthralgia, apoplexy, jaundice and diabetes in traditional medicines, and contains secoiridoid glycosides as the main active ingredients. In the present study, five new se... |
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The anti-inflammatory secoiridoid glycosides from gentianae scabrae radix: the root and rhizome of Gentiana scabra.
J. Nat. Med. 69 , 303-12, (2015) Gentianae Scabrae Radix is a well-known traditional medicine that is used for the treatment of hepatitis, cholecystitis and inflammatory diseases. It consists mainly of secoiridoid glycosides, with representatives of gentiopicroside, sweroside and swertiamari... |
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On involvement of transcription factors nuclear factor kappa-light-chain-enhancer of activated B cells, activator protein-1 and signal transducer and activator of transcription-3 in photodynamic therapy-induced death of crayfish neurons and satellite glial cells.
J. Biomed. Opt. 20 , 75004, (2015) Photodynamic therapy (PDT) is currently used in the treatment of brain tumors. However, not only malignant cells but also neighboring normal neurons and glial cells are damaged during PDT. In order to study the potential role of transcription factors-nuclear ... |
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A eudesmane-type sesquiterpene isolated from Pluchea odorata (L.) Cass. combats three hallmarks of cancer cells: Unrestricted proliferation, escape from apoptosis and early metastatic outgrowth in vitro.
Mutat. Res. 777 , 79-90, (2015) Pluchea odorata is ethno pharmaceutically used to treat inflammation-associated disorders. The dichloromethane extract (DME) was tested in the carrageenan-induced rat paw oedema assay investigating its effect on inflammation that was inhibited by 37%. Also an... |
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Cell death in amastigote forms of Leishmania amazonensis induced by parthenolide.
BMC Microbiol. 14 , 152, (2014) Leishmania amazonensis infection results in diverse clinical manifestations: cutaneous, mucocutaneous or visceral leishmaniasis. The arsenal of drugs available for treating Leishmania infections is limited. Therefore, new, effective, and less toxic leishmania... |
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Parthenolide induces autophagy via the depletion of 4E-BP1.
Biochem. Biophys. Res. Commun. 456(1) , 434-9, (2015) Parthenolide (PTL) is a sesquiterpene lactone isolated from feverfew and exhibits potent antitumor activity against various cancers. Many studies indicate that PTL treatment leads to apoptosis, however, the mechanism has not been defined. Here, we observed th... |
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Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives.
Acta Trop. 140 , 77-83, (2014) Malaria remains one of the world's most common infectious diseases, being responsible for more deaths than any other communicable disease except tuberculosis. There is strong evidence that tumour necrosis factor α and interleukin-1β are important contributors... |
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Cyclooxygenase-2-dependent oxidative stress mediates palmitate-induced impairment of endothelium-dependent relaxations in mouse arteries.
Biochem. Pharmacol. 91(4) , 474-82, (2014) Palmitic acid, one of the saturated free fatty acids, impairs cardiovascular function as manifested by inducing vascular inflammation, apoptosis and over-production of reactive oxygen species (ROS) although the origin for ROS remains unclear. The present stud... |