Protopanaxatriol
Protopanaxatriol structure
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Common Name | Protopanaxatriol | ||
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| CAS Number | 1453-93-6 | Molecular Weight | 476.732 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 590.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C30H52O4 | Melting Point | 261-263 °C | |
| MSDS | USA | Flash Point | 240.1±24.7 °C | |
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An integrated high resolution mass spectrometric data acquisition method for rapid screening of saponins in Panax notoginseng (Sanqi).
J. Pharm. Biomed. Anal. 109 , 184-91, (2015) The aim of this study was to develop a convenient method without pretreatments for nontarget discovery of interested compounds. The segment and exposure strategy, coupled with two mass spectrometer data acquisition methods was firstly proposed for screening t... |
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Adulteration and cultivation region identification of American ginseng using HPLC coupled with multivariate analysis.
J. Pharm. Biomed. Anal. 99 , 8-15, (2014) American ginseng (Panax quinquefolius) is originally grown in North America. Due to price difference and supply shortage, American ginseng recently has been cultivated in northern China. Further, in the market, some Asian ginsengs are labeled as American gins... |
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Cytochrome P450 CYP716A53v2 catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis in Panax ginseng.
Plant Cell Physiol. 53 , 1535-1545, (2012) Ginseng (Panax ginseng C.A. Meyer) is one of the most popular medicinal herbs, and the root of this plant contains pharmacologically active components, called ginsenosides. Ginsenosides, a class of tetracyclic triterpene saponins, are synthesized from dammare... |
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The in vitro structure-related anti-cancer activity of ginsenosides and their derivatives.
Molecules 16(12) , 10619-30, (2011) Panax ginseng has long been used in Asia as a herbal medicine for the prevention and treatment of various diseases, including cancer. The current study evaluated the cytotoxic potency against a variety of cancer cells by using ginseng ethanol extracts (RSE), ... |
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Fungal sensitivity to and enzymatic deglycosylation of ginsenosides.
Phytochemistry 78 , 65-71, (2012) A ginseng pathogen, Cylindrocarpon destructans, and five nonpathogens were tested for their sensitivity to a total ginsenoside fraction (T-GF), a protopanaxadiol-type ginsenoside fraction (PPD-GF) and a protopanaxatriol-type ginsenoside fraction (PPT-GF) from... |
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Effect of ginsenoside Rg1 on proliferation and neural phenotype differentiation of human adipose-derived stem cells in vitro.
Can. J. Physiol. Pharmacol. 92(6) , 467-75, (2014) To investigate whether ginsenoside Rg1 can promote neural phenotype differentiation of human adipose-derived stem cells (hASCs) in vitro.hASCs were isolated from lipo-aspirates, and characterized by specific cell markers and multilineage differentiation capac... |
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Ginsenoside-mediated blockade of 1,25-dihydroxyvitamin D3 inactivation in human liver and intestine in vitro.
J. Steroid Biochem. Mol. Biol. 141 , 94-103, (2014) The beneficial effects of vitamin D3 are exerted through 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the dihydroxy metabolite of vitamin D3. Hepatic and intestinal biotransformation of 1,25(OH)2D3 and modifiers of metabolic capacity could be important determinant... |
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Inhibitory effect of protopanaxatriol ginseng metabolite M4 on the production of corticosteroids in ACTH-stimulated bovine adrenal fasciculata cells.
Life Sci. 92(12) , 687-93, (2013) We investigated the pharmacological effects of saponins isolated from ginseng root and their metabolites, which occur by hydrolysis of the sugar moieties connecting the aglycone of saponins in the digestive tract, on the production of corticosteroids in bovin... |
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Simultaneous determination of ginsenoside (G-Re, G-Rg1, G-Rg2, G-F1, G-Rh1) and protopanaxatriol in human plasma and urine by LC-MS/MS and its application in a pharmacokinetics study of G-Re in volunteers.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(22) , 2011-7, (2011) Ginsenoside Re (G-Re) improved the memory function of experimental animals in a preclinical study. Several types of saponins including G-Rg1, G-Rg2, G-F1, G-Rh1, and protopanaxatriol (PPT) may be the metabolites of G-Re according to reports from preclinical t... |
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Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol.
J. Pharmacol. Sci. 109(4) , 504-10, (2009) Ginsenoside Rg1 has been reported to improve cognitive function in many memory-impaired animal models. However, little is known about the bioactivity of its metabolites in the central nervous system in vivo. In the present study, we employed the step through ... |