Creatinine
Creatinine structure
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Common Name | Creatinine | ||
|---|---|---|---|---|
| CAS Number | 60-27-5 | Molecular Weight | 113.118 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 184.3±23.0 °C at 760 mmHg | |
| Molecular Formula | C4H7N3O | Melting Point | 295 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 65.3±22.6 °C | |
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Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.
J. Clin. Invest. 125(2) , 607-20, (2015) Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited nephropathy responsible for 4%-10% of end-stage renal disease cases. Mutations in the genes encoding polycystin-1 (PC1, PKD1) or polycystin-2 (PC2, PKD2) cause ADPKD, and PKD1 mutation... |
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Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.
J. Chromatogr. A. 1361 , 265-76, (2014) This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse urine. Samples were obtained from a murine model that mimics... |
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Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1.
Placenta 36(4) , 446-53, (2015) Elevated circulating soluble FLT1 (sFLT1) levels seen in preeclampsia may play a role in its development. Aspirin is recommended for prevention of preeclampsia. We hypothesized that aspirin may inhibit the production of sFlt1.Placentas from women with and wit... |
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Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation.
Nat. Commun. 6 , 6218, (2015) Osteoporosis is caused by excessive activity of bone-degrading osteoclasts over bone-forming osteoblast. Standard antiosteolytic treatments inhibit bone resorption by inducing osteoclast loss, with the adverse effect of hindering also bone formation. Formatio... |
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Stratification of risk of death in severe acute alcoholic hepatitis using a panel of adipokines and cytokines.
Alcohol. Clin. Exp. Res. 38(11) , 2712-21, (2014) Dysregulated adipose tissue metabolism has been implicated in the pathogenesis of alcoholic liver disease in murine models. We aimed to characterize serum markers of adipose tissue metabolism and inflammation in patients with severe acute alcoholic hepatitis ... |
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Ret is critical for podocyte survival following glomerular injury in vivo.
Am. J. Physiol. Renal Physiol. 308(7) , F774-83, (2015) Podocyte injury and loss directly cause proteinuria and the progression to glomerulosclerosis. Elucidation of the mechanisms of podocyte survival and recovery from injury is critical for designing strategies to prevent the progression of glomerular diseases. ... |
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Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.
Naunyn Schmiedebergs Arch. Pharmacol. 387(9) , 849-59, (2014) Elevated polyol pathway enzyme activities and oxidative stress play an important role in the development and progression of diabetic nephropathy. Here, we investigated the beneficial influence of nigerloxin, a fungal metabolite and a potent aldose reductase i... |
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Hepatorenal protective effect of Antistax(®) against chemically-induced toxicity.
Pharmacogn. Mag. 11 , S173-81, (2015) Antioxidant natural products and chemoprevention are considered nowadays as an effective approach against health various disorders and diseases induced by oxidative stress or free radicals.The aim of this study was to assess the hepato- and nephroprotective a... |
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Safety and biocompatibility of carbohydrate-functionalized polyanhydride nanoparticles.
AAPS J. 17(1) , 256-67, (2015) Carbohydrate functionalization of nanoparticles allows for targeting of C-type lectin receptors. This family of pattern recognition receptors expressed on innate immune cells, such as macrophages and dendritic cells, can be used to modulate immune responses. ... |
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Pregnancy and lactation alter biomarkers of biotin metabolism in women consuming a controlled diet.
J. Nutr. 144(12) , 1977-84, (2014) Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant wom... |