Adenosine 5′-monophosphate disodium salt
Adenosine 5′-monophosphate disodium salt structure
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Common Name | Adenosine 5′-monophosphate disodium salt | ||
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| CAS Number | 149022-20-8 | Molecular Weight | 391.185 | |
| Density | N/A | Boiling Point | 798.5ºC at 760mmHg | |
| Molecular Formula | C10H12N5Na2O7P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 436.7ºC | |
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Regulation of AMPK by the ubiquitin proteasome system.
Am. J. Pathol. 178 , 4-11, (2011) The 5'-AMP-activated protein kinase (AMPK) functions as a metabolic fuel gauge that is activated in response to environmental stressors to restore cellular energy balance. In the heart, AMPK coordinates the activation of glucose and fatty acid metabolic pathw... |
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New strategies in prostate cancer: targeting lipogenic pathways and the energy sensor AMPK.
Clin. Cancer Res. 16 , 3322-3328, (2010) Although the role of metabolic syndrome (MS) and a high fat diet in prostate cancer (PCa) risk is still a matter of intense debate, it is becoming increasingly clear that obesity can cause perturbations in metabolic pathways that contribute to the pathogenesi... |
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Identification of a novel CaMKK substrate.
Biochem. Biophys. Res. Commun. 410 , 45-51, (2011) Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK) phosphorylates and activates specific downstream protein kinases including CaMKI, CaMKIV and 5'-AMP-activated protein kinase. In order to examine the variety of CaMKK-mediated signaling pathways, we se... |
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Extracellular ATP induces intracellular alpha-synuclein accumulation via P2X1 receptor-mediated lysosomal dysfunction.
Neurobiol. Aging 36(2) , 1209-20, (2015) The pathologic hallmark of Parkinson's disease (PD) is the accumulation of alpha-synuclein (αsyn) in susceptible neurons in the form of Lewy bodies and Lewy neurites. The etiology of PD remains unclear. Because brain injury has been suggested to facilitate αs... |
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5'-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.
Biosci. Rep. 32(2) , 197-213, (2012) In adult rat cardiac myocytes adrenaline decreased AMPK (AMP-activated protein kinase) activity with a half-time of approximately 4 min, decreased phosphorylation of AMPK (α-Thr172) and decreased phosphorylation of ACC (acetyl-CoA carboxylase). Inactivation o... |
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Sensitive and validated LC-MS/MS methods to evaluate mycophenolic acid pharmacokinetics and pharmacodynamics in hematopoietic stem cell transplant patients.
Biomed. Chromatogr. 29 , 1309-16, (2015) Monitoring of pharmacodynamics in addition to pharmacokinetics is one of strategies to individualize mycophenolate mofetil therapy. The purpose of this study was to develop sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods for evalua... |
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AICAR-Induced Activation of AMPK Inhibits TSH/SREBP-2/HMGCR Pathway in Liver.
PLoS ONE 10 , e0124951, (2015) Our previous study found that thyroid-stimulating hormone promoted sterol regulatory element-binding protein-2 (SREBP-2) expression and suppressed AMP-activated protein kinase (AMPK) activity in the liver, but it was unclear whether there was a direct link be... |