Piplartine
Piplartine structure
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Common Name | Piplartine | ||
|---|---|---|---|---|
| CAS Number | 20069-09-4 | Molecular Weight | 317.336 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 475.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C17H19NO5 | Melting Point | 124ºC | |
| MSDS | Chinese USA | Flash Point | 241.4±28.7 °C | |
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Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease.
Brain 138 , 3221-37, (2015) Polyglutamine diseases are a class of dominantly inherited neurodegenerative disorders for which there is no effective treatment. Here we provide evidence that activation of serotonergic signalling is beneficial in animal models of Machado-Joseph disease. We ... |
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Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways.
Acta Pharmacol. Sin. 36(3) , 362-74, (2015) To investigate the effects of piperlongumine (PL), an anticancer alkaloid from long pepper plants, on the primary myeloid leukemia cells from patients and the mechanisms of action.Human BM samples were obtained from 9 patients with acute or chronic myeloid le... |
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Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer.
J. Pharm. Sci. 104 , 4417-26, (2016) Very low oral bioavailability due to extensive pre-systemic metabolism and P-gp efflux has constrained the oral metronomic chemotherapy of docetaxel (DTX). There is tremendous need of compounds facilitating oral delivery of DTX. The research was aimed to inve... |
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Preformulation Studies on Piperlongumine.
PLoS ONE 11 , e0151707, (2016) Piperlongumine is a natural alkaloid extracted from piper plants which has been used traditionally for the treatment of certain diseases. This compound shows interesting in vitro pharmacological activity such as selective anticancer activity and higher cytoto... |