S(-)-5-FLUORO-8-HYDROXY-2-DIPROPYLAMINO-1,2,3,4-TETRAHYDRONAPHTHALENE HYDROCHLORIDE
S(-)-5-FLUORO-8-HYDROXY-2-DIPROPYLAMINO-1,2,3,4-TETRAHYDRONAPHTHALENE HYDROCHLORIDE structure
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Common Name | S(-)-5-FLUORO-8-HYDROXY-2-DIPROPYLAMINO-1,2,3,4-TETRAHYDRONAPHTHALENE HYDROCHLORIDE | ||
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| CAS Number | 127126-22-1 | Molecular Weight | 301.82700 | |
| Density | N/A | Boiling Point | 382ºC at 760 mmHg | |
| Molecular Formula | C16H25ClFNO | Melting Point | N/A | |
| MSDS | USA | Flash Point | 184.8ºC | |
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In vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, WAY-100,635 and (S)-(-)-UH-301 at rat brain monoamine receptors.
Eur. Neuropsychopharmacol. 9 , 15-19, (1999) The receptor-mediated control of brain monoamine synthesis was used to examine the in vivo intrinsic efficacy of the 5-HT1A receptor antagonists NAD-299, S(-)-UH-301 and WAY-100,635. The rate of monoamine synthesis was estimated by measuring the accumulation ... |
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Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.
J. Pharmacol. Exp. Ther. 258 , 58, (1991) The selective 5-hydroxytryptamine (5-HT1A) receptor agonist 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT) induces a large number of pharmacological effects. In the present study we demonstrate that a novel 8-OH-DPAT analog, (S)-5-fluoro-8-hydroxy-2-(dipropy... |
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The 5-HT1A receptor selective ligands, (R)-8-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons.
Naunyn Schmiedebergs Arch. Pharmacol. 347 , 353-362, (1993) The effects of the selective 5-HT1A receptor agonist (R)-8-hydroxy-2(di-n-propylamino)tetralin [(R)-8-OH-DPAT] and the novel 5-HT1A antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)-tetralin [(S)-UH-301] were studied with regard to the firing pattern of sin... |
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(S)-UH-301 antagonizes (R)-8-OH-DPAT-induced cardiovascular effects in the rat.
Eur. J. Pharmacol. 199 , 367, (1991) The 5-HT1A-receptor antagonist (S)-UH-301 (S)-5-fluoro-8-hydroxy-2- (dipropylamino)tetralin) completely antagonized the hypotension and bradycardia induced by (R) = 8-OH DPAT [R)-8-hydroxy-2- (dipropylamino)tetralin) in conscious rats. (S)-UH-301 alone induce... |
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Synthesis and pharmacology of the enantiomers of UH301: opposing interactions with 5-HT1A receptors.
Chirality 8 , 531-544, (1996) The (S)-enantiomer of 5-fluoro-8-hydroxy-2-(dipropylamino) tetralin [(S)-2a; (S)-UH301] was the first reported 5-HT1A receptor antagonist. We now give a full account on the synthetic effort leading to the preparation of the racemate and the enantiomers of 2a.... |