VES
VES structure
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Common Name | VES | ||
|---|---|---|---|---|
| CAS Number | 4345-03-3 | Molecular Weight | 530.779 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 625.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C33H54O5 | Melting Point | ~76 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 187.0±25.0 °C | |
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Influence of process and formulation parameters on dissolution and stability characteristics of Kollidon® VA 64 hot-melt extrudates.
AAPS PharmSciTech 16(2) , 444-54, (2015) The objective of the present study was to investigate the effects of processing variables and formulation factors on the characteristics of hot-melt extrudates containing a copolymer (Kollidon® VA 64). Nifedipine was used as a model drug in all of the extruda... |
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Shrapnel nanoparticles loading docetaxel inhibit metastasis and growth of breast cancer.
Biomaterials 64 , 10-20, (2015) Metastasis is one of the major obstacles for the successful therapy of breast cancer. To inhibit the metastasis and growth of breast cancer simultaneously, a new docetaxel (DTX) loaded shrapnel nano delivery system with the reduction- and enzyme-sensitive pro... |
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p66Shc longevity protein regulates the proliferation of human ovarian cancer cells.
Mol. Carcinog. 54 , 618-31, (2015) p66Shc functions as a longevity protein in murine and exhibits oxidase activity in regulating diverse biological activities. In this study, we investigated the role of p66Shc protein in regulating ovarian cancer (OCa) cell proliferation. Among three cell line... |
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Preparation of intravenous injection nanoformulation of VESylated gemcitabine by co-assembly with TPGS and its anti-tumor activity in pancreatic tumor-bearing mice.
Int. J. Pharm. 495 , 792-7, (2015) Our recent publication showed that VES-dFdC nanocapsules in pure water could be obtained via the self-assembling of VES-dFdC prodrug synthesized by coupling gemcitabine (dFdC) with vitamin E succinate (VES). To prepare the intravenous injection nanoformulatio... |
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Hydrogen-bonded and reduction-responsive micelles loading atorvastatin for therapy of breast cancer metastasis.
Biomaterials 35(26) , 7574-87, (2014) Metastasis is one of the major obstacles for the successful therapy of breast cancer. Although increased candidate drugs targeting cancer metastasis are tested, their clinical translation is limited by either serve toxicity or low efficacy. In present work, a... |
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Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.
Cell Death Dis. 6 , e1749, (2015) Respiratory complex II (CII, succinate dehydrogenase, SDH) inhibition can induce cell death, but the mechanistic details need clarification. To elucidate the role of reactive oxygen species (ROS) formation upon the ubiquinone-binding (Qp) site blockade, we su... |
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alpha-Tocopheryl succinate as a scaffold to develop potent inhibitors of breast cancer cell adhesion.
J. Med. Chem. 52 , 5642-8, (2009) This study is aimed at the pharmacological exploitation of alpha-tocopheryl succinate (1) to develop potent antiadhesion agents. Considering the structural cooperativity between the phytyl chain and the carboxylic terminus in determining the antiadhesion acti... |
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Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.
Int. J. Radiat. Biol. 86 , 12-21, (2010) The purpose of this study was to further elucidate the role of granulocyte-colony stimulating factor (G-CSF)-induced in response to alpha-tocopherol succinate (TS) administration in protecting mice from total body irradiation (TBI).The dose, route, and schedu... |
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Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor.
Cytokine 56(2) , 411-21, (2011) The purpose of this study was to elucidate the role of granulocyte colony-stimulating factor (G-CSF) induced by α-tocopherol succinate (TS) in protecting mice from total-body irradiation. CD2F1 mice were injected with a radioprotective dose of TS and the leve... |
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Dietary RRR-α-tocopherol succinate attenuates lipopolysaccharide-induced inflammatory cytokines secretion in broiler chicks.
Br. J. Nutr. 104 , 1796-1805, (2010) The anti-inflammatory effects of two esters of a-tocopherol (α-TOH), all-rac-α-TOH acetate (DL-α-TOA) and RRR-α-TOH succinate (D-α-TOS), on broilers repeatedly challenged with lipopolysaccharide (LPS) were investigated. Three hundred and twenty 1-d-old broile... |