cinnarizine
cinnarizine structure
|
Common Name | cinnarizine | ||
|---|---|---|---|---|
| CAS Number | 298-57-7 | Molecular Weight | 368.514 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 509.2±38.0 °C at 760 mmHg | |
| Molecular Formula | C26H28N2 | Melting Point | 117-120ºC | |
| MSDS | Chinese USA | Flash Point | 229.8±14.6 °C | |
|
Iron oxide induced enhancement of mucoadhesive potential of Eudragit RLPO: formulation, evaluation and optimization of mucoadhesive drug delivery system.
Expert Opin. Drug Deliv. 10(9) , 1179-91, (2013) The objective of the study was to investigate the effect of iron oxide in the development of mucoadhesive tablets of cinnarizine using Eudragit RLPO polymer. A simplex lattice design was employed for optimizing the drug delivery system.Different concentration... |
|
|
A combination turbidity and supernatant microplate assay to rank-order the supersaturation limits of early drug candidates.
J. Pharm. Sci. 103(10) , 3022-32, (2014) A unique opportunity exists at the drug discovery stage to overcome inherently poor solubility by selecting drug candidates with superior supersaturation propensity. Existing supersaturation assays compare either precipitation-resistant or precipitation-inhib... |
|
|
Factors influencing crystal growth rates from undercooled liquids of pharmaceutical compounds.
J. Phys. Chem. B 118(33) , 9974-82, (2014) Amorphous forms of drugs are increasingly being used to deliver poorly water-soluble compounds. Therefore, understanding the magnitude and origin of differences in crystallization kinetics is highly important. The goal of this study was to better understand t... |
|
|
An in vivo antilymphatic screen in zebrafish identifies novel inhibitors of mammalian lymphangiogenesis and lymphatic-mediated metastasis.
Mol. Cancer Ther. 13(10) , 2450-62, (2014) The growth of new lymphatic vessels (lymphangiogenesis) in tumors is an integral step in the metastatic spread of tumor cells, first to the sentinel lymph nodes that surround the tumor and then elsewhere in the body. Currently, no selective agents designed to... |
|
|
Circumvention of inherent or acquired cytotoxic drug resistance in vitro using combinations of modulating agents.
Anticancer Res. 33(10) , 4381-7, (2013) Modulating agents are used to circumvent drug resistance in the clinical setting. However achievable serum concentrations are often lower than those which are optimal in vitro. Combination of modulating agents with non-overlapping toxicities may overcome this... |
|
|
In vitro efficacy of cinnarizine against lymphoma and multiple myeloma.
Anticancer Res. 35(2) , 835-41, (2015) Multiple myeloma, a well-known but still incurable disease, is a hematological malignancy of B-lymphocytes. While standard chemotherapy regimens have been used for years, novel agents, such as lenalidomide and bortezomib, have become an essential part of toda... |
|
|
Lipid-based formulations solidified via adsorption onto the mesoporous carrier Neusilin® US2: effect of drug type and formulation composition on in vitro pharmaceutical performance.
J. Pharm. Sci. 103(6) , 1734-46, (2014) The current study determined the extent to which the desorption of lipid-based formulations (LBFs) from a mesoporous magnesium aluminometasilicate (Neusilin®-US2) carrier is governed by drug properties, LBF composition, and LBF-to-adsorbent ratio. A secondary... |
|
|
Improving the prognosis ways of central genesis and management option in infertile women.
Georgian Med. News (212) , 19-23, (2012) To study central genesis of disfunctional menstrual disorders was based particulary on electroencephalography and find out efficacy of pathogenetic management in infertile women with central forms of oligomenorrhoea and amenorrhoea compared to generally accep... |
|
|
Palladium-catalyzed vinylation of aminals with simple alkenes: a new strategy to construct allylamines.
J. Am. Chem. Soc. 134(51) , 20613-6, (2012) A novel, highly selective palladium-catalyzed vinylation reaction for the direct synthesis of allylic amines from styrenes and aminals has been established. The utility of this method was also demonstrated by the rapid synthesis of cinnarizine from aldehydes,... |
|
|
[Drug-induced parkinsonism].
Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 112(8) , 76-81, (2012)
|