Dextromethorphan Hydrobromide Monohydrate
Dextromethorphan Hydrobromide Monohydrate structure
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Common Name | Dextromethorphan Hydrobromide Monohydrate | ||
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| CAS Number | 6700-34-1 | Molecular Weight | 370.324 | |
| Density | N/A | Boiling Point | 486.1ºC at 760 mmHg | |
| Molecular Formula | C18H28BrNO2 | Melting Point | 116-119°C | |
| MSDS | USA | Flash Point | 11 °C | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Influence of Carbopol 71G-NF on the release of dextromethorphan hydrobromide from extended-release matrix tablets.
Pharm. Dev. Technol. 18(5) , 971-81, (2013) The objective of this study was to evaluate the potential of Carbopol(®) 71G-NF on the release of dextromethorphan hydrobromide (DM) from matrix tablets in comparison with hydroxypropyl methylcellulose (HPMC(®) K15M) and Eudragit(®) L100-55 polymers. Controll... |
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Hepatic Cyp2d and Cyp26a1 mRNAs and activities are increased during mouse pregnancy.
Drug Metab. Dispos. 41(2) , 312-9, (2013) There is considerable evidence that drug disposition is altered during human pregnancy and based on probe drug studies, CYP2D6 activity increases during human pregnancy. The aim of this study was to determine whether the changes of CYP2D6 activity observed du... |
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Simultaneous determination of dextromethorphan and dextrophan in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Pharmazie 67(6) , 485-9, (2012) A highly selective and sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for quantitating dextromethorphan (DXM) and its metabolite dextrophan (DXO) in rat plasma using pirfenidone as an internal standard.... |
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Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy.
Ther. Drug Monit. 34(4) , 422-31, (2012) An association between CYP2D6 variation and clinical outcomes among women with breast cancer treated with tamoxifen (TAM) has been demonstrated, such that the presence of 2 functional CYP2D6 alleles was associated with better clinical outcomes. This associati... |
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Suicidal and homicidal behaviors related to dextromethorphan abuse in a middle-aged woman.
J. Addict. Med. 7(2) , 143-4, (2013) Over-the-counter medications available without prescriptions are generally viewed safe for public consumption. However, when used in excess, these medications can lead to adverse consequences. There are multiple over-the-counter medications that have potentia... |
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Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes.
Phytomedicine 20(3-4) , 367-74, (2013) Previous studies have shown that major tanshinones isolated from Danshen (Salvia miltiorrhiza) inhibited human and rat CYP450 enzymes-mediated metabolism of model probe substrates, with potential in causing herb-drug interactions. Miltirone, another abietane ... |
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How often do false-positive phencyclidine urine screens occur with use of common medications?
Clin. Toxicol. (Phila.) 51(6) , 493-6, (2013) Previous reports describe false-positive urine immunoassay screens for phencyclidine (PCP) associated with use of tramadol, dextromethorphan, or diphenhydramine. The likelihood of these false positives is unknown.We sought to find the relative frequency of fa... |
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Acute cognitive effects of high doses of dextromethorphan relative to triazolam in humans.
Drug Alcohol Depend. 128(3) , 206-13, (2013) Although concerns surrounding high-dose dextromethorphan (DXM) abuse have recently increased, few studies have examined the acute cognitive effects of high doses of DXM. The aim of this study was to compare the cognitive effects of DXM with those of triazolam... |