[11C]-(-)-N-n-Propylnorapomorphine
![[11C]-(-)-N-n-Propylnorapomorphine Structure](https://image.chemsrc.com/caspic/246/18426-20-5.png)
[11C]-(-)-N-n-Propylnorapomorphine structure
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Common Name | [11C]-(-)-N-n-Propylnorapomorphine | ||
|---|---|---|---|---|
| CAS Number | 18426-20-5 | Molecular Weight | 295.37600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H21NO2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radioligand binding.
Synapse 64(9) , 699-703, (2010) In vitro, D(2) dopamine receptors (DAR) can exist in low- and high-affinity states for agonists and increases of D(2) receptors in high-affinity state have been proposed to underlie DA receptor supersensitivity in vivo. Deletion of the gene for dopamine beta-... |
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Effects of isomers of apomorphines on dopamine receptors in striatal and limbic tissue of rat brain.
Life Sci. 37 , 1051, (1985) The optical isomers of apomorphine (APO) and N-propylnorapomorphine (NPA) were interacted with three biochemical indices of dopamine (DA) receptors in extrapyramidal and limbic preparations of rat brain tissue. There were consistent isomeric preferences for t... |
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Agonist binding fraction of dopamine D2/3receptors in rat brain: A quantitative autoradiographic study
Neurochem. Int. 56 , 747-752, (2010) There has arisen considerable interest in the study of dopamine D 2/3 agonist binding sites by positron emission tomography (PET), based on the claim that agonist sites represent a functional subset of the total number of sites labeled by more conventional an... |
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The A(2B)-D(2) receptor interaction that controls carotid body catecholamines release locates between the last two steps of hypoxic transduction cascade.
Adv. Exp. Med. Biol. 648 , 161-8, (2009) We have recently demonstrated that adenosine controls the release of catecholamines (CA) from carotid body (CB) acting on A(2B) receptors. Here, we have investigated the hypothesis that this control is exerted via an interaction between adenosine A(2B) and do... |
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Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys.
J. Pharmacol. Exp. Ther. 321(3) , 1135-43, (2007) Cocaine-heroin combinations ("speedballs") are commonly self-administered by polydrug abusers. Speedball self-administration may reflect in part an enhancement of the reinforcing effects of the drug combination compared with either drug alone. The present stu... |
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Mechanisms of inverse agonist action at D2 dopamine receptors.
Br. J. Pharmacol. 145(1) , 34-42, (2005) Mechanisms of inverse agonist action at the D2(short) dopamine receptor have been examined. Discrimination of G-protein-coupled and -uncoupled forms of the receptor by inverse agonists was examined in competition ligand-binding studies versus the agonist [3H]... |
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Co-operativity in agonist binding at the D2 dopamine receptor: evidence from agonist dissociation kinetics.
J. Neurochem. 112(6) , 1442-53, (2010) There is much evidence to suggest that G protein coupled receptors exist as oligomers but the relevance to their function is unclear. We have, therefore, examined the binding of the radiolabelled agonist [(3)H]NPA to membranes of CHO cells expressing the D(2)... |
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Synthesis and evaluation of novel pyridine based PLG tripeptidomimetics.
Org. Biomol. Chem. 6(9) , 1647-54, (2008) Analogues of the pyridine based PLG (Pro-Leu-Gly-NH(2)) peptidomimetic were synthesized and evaluated as dopamine modulating agents. Modifications in the position corresponding to the leucine side chain in PLG afforded derivatives , and , substituted with H, ... |