(20R)-17,20-Dihydroxypregn-4-en-3-one
(20R)-17,20-Dihydroxypregn-4-en-3-one structure
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Common Name | (20R)-17,20-Dihydroxypregn-4-en-3-one | ||
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| CAS Number | 1662-06-2 | Molecular Weight | 332.48 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 487.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H32O3 | Melting Point | 201-202ºC | |
| MSDS | USA | Flash Point | 262.5±25.2 °C | |
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Changes in expression of genes encoding gonadotropin subunits and growth hormone/prolactin/somatolactin family hormones during final maturation and freshwater adaptation in prespawning chum salmon.
Endocrine 20(1-2) , 23-34, (2003) The pituitary levels of mRNAs encoding gonadotropin (GTH) subunits (GTH alpha2 and IIbeta), prolactin (PRL), and somatolactin (SL) increased in chum salmon during the last stages of spawning migration. In the present study, changes in pituitary levels of mRNA... |
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Dispersion of cyclin B mRNA aggregation is coupled with translational activation of the mRNA during zebrafish oocyte maturation.
Dev. Biol. 229(2) , 421-31, (2001) Cyclin B mRNA stored in immature zebrafish oocytes is translationally activated upon the stimulation of 17alpha,20beta-dihydroxy-4-pregnen-3-one (17alpha,20beta-DP), an event prerequisite for initiating oocyte maturation in this species. We investigated local... |
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Epidermal growth factor receptor binding and biological activity in the ovary of goldfish, Carassius auratus.
Am. J. Physiol. 270(5 Pt 2) , R1065-72, (1996) The receptor binding and biological activity of epidermal growth factor-urogastrone (EGF) was characterized in the follicle-enclosed goldfish oocyte. The binding of 125I-labeled mouse EGF (mEGF) to goldfish ovarian membrane preparation was peptide specific, s... |
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Diethylstilbestrol induces fish oocyte maturation.
Proc. Natl. Acad. Sci. U. S. A. 101(10) , 3686-90, (2004) An endocrine-disrupting chemical, diethylstilbestrol (DES), a nonsteroidal estrogen, triggers oocyte maturation in fish. The morphology (the time course of the change in germinal vesicle breakdown) and an intracellular molecular event (the de novo synthesis o... |
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Steroid metabolism by ovarian follicles of the sea bass Dicentrarchus labrax.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 125(1) , 85-91, (2000) Ovarian samples from fear sea bass, Dicentrarchus labrax, were collected for the in vitro incubations during the spawning period. Follicles with fully developed vitellogenic oocytes showing central germinal vesicle (stage I follicles) and follicles with oocyt... |
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Effects of the aromatase inhibitor Fadrozole on plasma sex steroid secretion and ovulation rate in female coho salmon, Oncorhynchus kisutch, close to final maturation.
Gen. Comp. Endocrinol. 113(2) , 221-9, (1999) Plasma levels of 17beta-estradiol, 17alpha, 20beta-dihydroxy-4-pregnen-3-one (17alpha,20beta-P), and testosterone were measured in adult female coho salmon in late vitellogenesis, approximately 1.5 months before spawning and just before and following intraper... |
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Effects of 17alpha,20beta-dihydroxy-4-pregnen-3-one on cortisol production by rainbow trout interrenal tissue in vitro.
Gen. Comp. Endocrinol. 107(2) , 172-81, (1997) Physiological levels of 17alpha,20beta-dihydroxy-4-pregnen-3-one (17, 20-P) stimulated time- and dose-dependent increases in cortisol production by rainbow trout (Oncorhynchus mykiss) interrenal tissue cultured in vitro. Significant stimulation occurred in re... |
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20beta-Hydroxysteroid dehydrogenase of the Japanese eel ovary: its cellular localization and changes in the enzymatic activity during sexual maturation.
Gen. Comp. Endocrinol. 122(1) , 109-15, (2001) In many species of teleost, 20beta-hydroxysteroid dehydrogenase (20beta-HSD) is a key steroidogenic enzyme in the production of the oocyte maturation-inducing steroid (MIS), 17alpha, 20beta-dihydroxy-4-pregnen-3-one. In this study, 20beta-HSD in the ovary of ... |
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Dopamine D2 receptors and secretion of FSH and LH: role of sexual steroids on the pituitary of the female rainbow trout.
Gen. Comp. Endocrinol. 127(2) , 198-206, (2002) The role of sexual steroids in the modulation of a dopaminergic inhibitory tone on FSH and LH release was studied in the rainbow trout. The experiments were performed on previtellogenic trout, implanted or not with estradiol (E(2)), and vitellogenic trout. E(... |
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Follicle and extrafollicular tissue interaction in 17alpha,20beta-dihydroxy-4-pregnen-3-one-stimulated ovulation and prostaglandin synthesis in the yellow perch (Perca flavescens) ovary.
Gen. Comp. Endocrinol. 105(1) , 121-6, (1997) Intact (attached to extrafollicular (EF) tissue) yellow perch follicles ovulate in vitro when stimulated with the steroid, 17alpha, 20beta-dihydroxy-4-pregnen-3-one (17,20-PG). However, follicles isolated from EF tissue will not ovulate under 17,20-PG stimula... |