Naloxone benzoylhydrazone
Naloxone benzoylhydrazone structure
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Common Name | Naloxone benzoylhydrazone | ||
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| CAS Number | 119630-94-3 | Molecular Weight | 445.51000 | |
| Density | 1.44g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H27N3O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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The role of nociceptin in cognition.
Brain Res. 848(1-2) , 167-73, (1999) The physiological role of the modulation via the nociceptin receptor is still unclear. Here we report the role of the nociceptin system in learning and memory. Nociceptin-knockout mice possess greater learning ability in the water maze task, show an enhanced ... |
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Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors.
Br. J. Pharmacol. 147(4) , 360-70, (2006) 1. In the present study, we examined the pharmacological activity of the putative kappa3-opioid receptor agonist naloxone benzoylhydrazone (NalBzoH) at recombinant human opioid receptors individually expressed in Chinese hamster ovary (CHO) cells and native o... |
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Improvement by low doses of nociceptin on scopolamine-induced impairment of learning and/or memory.
Eur. J. Pharmacol. 395(2) , 149-56, (2000) The effects of fmol doses of nociceptin/orphanin FQ on scopolamine-induced impairment of learning and/or memory were examined using spontaneous alternation of Y-maze and step-down type passive avoidance tasks. While fmol doses of nociceptin alone had no effec... |
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Peripheral orphanin FQ/nociceptin analgesia in the mouse.
Life Sci. 64(22) , 2021-8, (1999) Orphanin FQ/Nociceptin (OFQ/N) administered peripherally was an effective analgesic in the tailflick test in mice (ED50 16.3 microg). It had a peak effect at 5 min and lasted up to 30 min. The kappa3 analgesic naloxone benzoylhydrazone was also active periphe... |
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Autoradiography in opioid triple knockout mice reveals opioid and opioid receptor like binding of naloxone benzoylhydrazone.
Neuropharmacology 48(2) , 228-35, (2005) Naloxone benzoylhydrazone (NalBzoH) is a ligand used to study opioid receptors. It has been suggested to act at a novel kappa3 receptor but also appears to bind to classical opioid receptors, and possibly the ORL1 receptor. We have used opioid receptor triple... |
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G protein activation and cyclic AMP modulation by naloxone benzoylhydrazone in distinct layers of rat olfactory bulb.
Br. J. Pharmacol. 143(5) , 638-48, (2004) 1 Naloxone benzoylhydrazone (NalBzoH) has initially been developed as an agonist of the pharmacologically defined kappa3-opioid receptor and has recently been employed as an antagonist at the opioid receptor-like (ORL1) receptor. In the present study, we inve... |
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Binding of GTPgamma[35S] is regulated by GDP and receptor activation. Studies with the nociceptin/orphanin FQ receptor.
Br. J. Pharmacol. 159(6) , 1286-93, (2010) We have examined the effects of ligand efficacy and receptor density on the binding of guanosine 5'-[gamma-thio]triphosphate (GTPgammaS) and GDP to the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP)-coupled G-proteins.In GTPgamma[(35)S] binding experim... |
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Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro.
Am. J. Physiol. Gastrointest. Liver Physiol. 281(1) , G237-46, (2001) Actions of nociceptin on electrical and synaptic behavior of morphologically and neurochemically identified neurons in the guinea pig duodenal myenteric plexus were studied with conventional techniques. Nociceptin hyperpolarized the membrane potential in 104 ... |
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Effects of naloxone benzoylhydrazone on native and recombinant nociceptin/orphanin FQ receptors.
Can. J. Physiol. Pharmacol. 80(5) , 407-12, (2002) We have studied the effects of naloxone benzoylhydrazone (NalBzoH) at recombinant human OP4 receptors expressed in Chinese hamster ovary (CHO) cells (CHOhOP4) and native OP4 sites in isolated tissues from various species. In CHOhOP4 membranes, nociceptin (NC)... |
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Acetyl-RYYRIK-NH(2) is a highly efficacious OP(4) receptor agonist in the cardiovascular system of anesthetized rats.
Peptides 21 , 1875, (2000) Nociceptin, the endogenous ligand of the OP(4) or ORL(1) (opioid receptor-like(1)) receptor, decreases blood pressure and heart rate in anesthetized rats. Since the OP(4) receptor antagonist [Phe(1)Psi(CH(2)-NH)Gly(2)]-nociceptin(1-13)NH(2) possesses an agoni... |