SC-66
SC-66 structure
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Common Name | SC-66 | ||
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| CAS Number | 871361-88-5 | Molecular Weight | 276.332 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 514.5±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H16N2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 260.0±36.5 °C | |
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Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells.
Oncotarget 6(3) , 1707-22, (2015) Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony formation and induced apoptosis in H... |
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p22phox confers resistance to cisplatin, by blocking its entry into the nucleus.
Oncotarget 6(6) , 4110-25, (2015) Cisplatin (CDDP) is a potent chemotherapeutic agent but resistance to the drug remains a major challenge in cancer treatment. To evaluate the efficacy of CDDP in oral squamous cell carcinoma (OSCC), we found that p22phox was highly expressed in CDDP-resistant... |
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PCNA-interacting peptides reduce Akt phosphorylation and TLR-mediated cytokine secretion suggesting a role of PCNA in cellular signaling.
Cell. Signal. 27 , 1478-87, (2015) Proliferating cell nuclear antigen (PCNA), commonly known as a nuclear protein essential for regulation of DNA replication, DNA repair, and epigenetics, has recently been associated with multiple cytosolic functions. Many proteins containing one of the two kn... |
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Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells.
Cell Death Dis. 6 , e2005, (2015) Rasfonin is a fungal secondary metabolite with demonstrated antitumor effects. However, the underlying mechanism of the regulatory role in autophagy initiated by rasfonin is largely unknown. Moreover, the function of Akt to positively mediate the induced auto... |