D-Mannosamine hydrochloride
D-Mannosamine hydrochloride structure
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Common Name | D-Mannosamine hydrochloride | ||
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| CAS Number | 5505-63-5 | Molecular Weight | 215.632 | |
| Density | N/A | Boiling Point | 532.5ºC at 760 mmHg | |
| Molecular Formula | C6H14ClNO5 | Melting Point | 168ºC (dec.) | |
| MSDS | USA | Flash Point | 275.8ºC | |
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Sialidases as regulators of bioengineered cellular surfaces.
Glycobiology 25 , 784-91, (2015) Human sialidases (NEUs) catalyze the removal of N-acetyl neuraminic acids from the glycome of the cell and regulate a diverse repertoire of nominal cellular functions, such as cell signaling and adhesion. A greater understanding of their substrate permissivit... |
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Mass spectrometric analysis of products of metabolic glycan engineering with azido-modification of sialic acids.
Anal. Bioanal. Chem 407 , 8945-58, (2015) Metabolic engineering of glycans present on antibodies and other glycoproteins is becoming an interesting research area for improving our understanding of the glycome. With knowledge of the sialic acid biosynthetic pathways, the experiments described in this ... |
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Conjunctival vaccination against Brucella ovis in mice with mannosylated nanoparticles.
J. Control. Release 162(3) , 553-60, (2012) The use of sub-unit vaccines can solve some drawbacks associated with traditional attenuated or inactivated ones. However, in order to improve their immunogenicity, these vaccines needs to be associated to an appropriate adjuvant which, adequately selected, m... |
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A new route for the synthesis of Streptococcus pneumoniae 19F and 19A capsular polysaccharide fragments avoiding the beta-mannosamine glycosylation step.
Carbohydr. Res. 344(12) , 1442-8, (2009) The recently described [Attolino, E.; Bonaccorsi, F.; Catelani, G.; D'Andrea, F. Carbohydr. Res. 2008, 343, 2545-2556.] beta-D-MaNAcp-(1-->4)-beta-D-Glcp thiophenyl glycosyl donor 3 was used in alpha-glycosylation reactions of OH-2 and OH-3 of the suitably pr... |
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Efficient metabolic engineering of GM3 on tumor cells by N-phenylacetyl-D-mannosamine.
Biochemistry 45(11) , 3733-9, (2006) Abnormal carbohydrates expressed on tumor cells, which are termed tumor-associated carbohydrate antigens (TACAs), are potential targets for the development of cancer vaccines. However, immune tolerance to TACAs has severely hindered progress in this area. To ... |
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Sialic acid (N-acetyl neuraminic acid) utilization by Bacteroides fragilis requires a novel N-acetyl mannosamine epimerase.
J. Bacteriol. 191(11) , 3629-38, (2009) We characterized the nanLET operon in Bacteroides fragilis, whose products are required for the utilization of the sialic acid N-acetyl neuraminic acid (NANA) as a carbon and energy source. The first gene of the operon is nanL, which codes for an aldolase tha... |
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Metabolic oligosaccharide engineering with N-Acyl functionalized ManNAc analogs: cytotoxicity, metabolic flux, and glycan-display considerations.
Biotechnol. Bioeng. 109(4) , 992-1006, (2012) Metabolic oligosaccharide engineering (MOE) is a maturing technology capable of modifying cell surface sugars in living cells and animals through the biosynthetic installation of non-natural monosaccharides into the glycocalyx. A particularly robust area of i... |
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Metal chelation by the common 2-amino-2-deoxy-, 2-N-acetylamino-2-deoxy-, and 2-deoxy-hexoses.
Dalton Trans. 39(23) , 5544-55, (2010) The chelating properties of the common aldohexoses d-glucose, d-mannose, and d-galactose are characteristically modified in 2-substituted derivatives. The 2-amino-2-deoxy-aldohexoses provide mono- and bis-metallisable anionic ligands after their reaction with... |
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Efficient biotinylation of methacryloyl-functionalized nonadherent cells for formation of cell microarrays.
Chem. Commun. (Camb.) 47(37) , 10329-31, (2011) In order to obtain cell microarrays formed with human promyelocytic leukemia cells (HL-60), biotinylation of methacryloyl-functionalized HL-60 cells was performed via a thiol-ene reaction with thiol-terminated 4-arm poly(ethylene glycol) (PEG(4)10K-SH). Bioti... |
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High-throughput analysis of hexosamine using a colorimetric method.
Anal. Biochem. 408(1) , 160-2, (2011) A 96-well plate method was developed for analysis of total hexosamine content in biological samples. Four hexosamine monomer derivatives-glucosamine hydrochloride, glucosamine sulfate, galactosamine hydrochloride, and mannosamine hydrochloride-were examined f... |