Bradykinin Fragment 1-5
Bradykinin Fragment 1-5 structure
|
Common Name | Bradykinin Fragment 1-5 | ||
|---|---|---|---|---|
| CAS Number | 23815-89-6 | Molecular Weight | 572.65600 | |
| Density | 1.46g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C27H40N8O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
|
Angiotensin-converting enzyme inhibition and smoking potentiate the kinin response to cardiopulmonary bypass.
Clin. Pharmacol. Ther. 76(4) , 379-87, (2004) This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB).The effects of CPB on concentrations of bradykinin and its metabolite bradykinin 1-5 ... |
|
|
Thrombostatin inhibits cyclic flow variations in stenosed canine coronary arteries.
Thromb. Haemost. 86(5) , 1296-304, (2001) Thrombostatins are a group of compounds based upon a breakdown product of bradykinin, RPPGF. They inhibit alpha-thrombin-induced platelet activation by binding to protease activated receptor 1 and, at a lower affinity, by interacting with thrombin's active si... |
|
|
Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.
J. Thromb. Haemost. 6(5) , 837-45, (2008) Novel pentapeptides called Thrombostatin FM compounds consisting mostly of D-isomers and unusual amino acids were prepared based upon the stable angiotensin converting enzyme breakdown product of bradykinin - RPPGF.These peptides are direct thrombin inhibitor... |
|
|
Bradykinin metabolism in rat hind limbs.
Shock 10(2) , 146-52, (1998) The purpose of this study was to assess the capacity of perfused rat hind limbs, the majority of which is skeletal muscle, to inactivate bradykinin (BK), and to compare the BK degrading capacity of rat hind limbs with the BK degrading capacities of rat lung a... |
|
|
Oral thrombostatin FM19 inhibits prostate cancer.
Thromb. Haemost. 104(5) , 1044-8, (2010) Thrombin stimulates proliferation, invasion and metastasis by cleaving protease-activated receptor 1 (PAR1) on human prostate cancer cells. Current direct thrombin inhibitors pose risks for bleeding in the cancer patients. We have developed an oral reversible... |
|
|
Mapping the interaction of bradykinin 1-5 with the exodomain of human protease activated receptor 4.
FEBS Lett. 579(1) , 25-9, (2005) The angiotensin converting enzyme breakdown product of bradykinin, bradykinin 1-5 (RPPGF), inhibits thrombin-induced human or mouse platelet aggregation. RPPGF binds to the exodomain of human protease-activated receptor 1 (PAR1). Studies determined if RPPGF a... |
|
|
Blockade of bradykinin B(2) receptor suppresses acute pancreatitis induced by obstruction of the pancreaticobiliary duct in rats.
Br. J. Pharmacol. 135(1) , 29-36, (2002) 1. The involvement of bradykinin (BK) B(2) receptor in acute pancreatitis induced by pancreaticobiliary duct ligation was investigated in rats. 2. The activities of amylase and lipase in the serum, the water content of the pancreas, and vacuolization of the a... |
|
|
A daughter of bradykinin that protects against septicaemia.
Expert Opin. Investig. Drugs 10(8) , 1567-9, (2001) When the defence response of the body to infectious bacteria fails, septic shock ensues with hypotension and death. RPPGF,(1-5)-bradykinin, was until recently considered to be an active metabolite of bradykinin. In an animal model of septicaemia (lipopolysacc... |
|
|
Conformationally restricted analogs of the direct thrombin inhibitor FM 19
Bioorg. Med. Chem. 19(24) , 7425-34, (2011) The serine protease thrombin plays several key roles in the clotting cascade within the hemostatic system, such as in fibrin formation and platelet activation. Thus, development of an inhibitor that binds to the enzyme's active site (a direct thrombin inhibit... |
|
|
Utilization of a radioimmunoassay to detect the generation of Arg-Pro-Pro-Gly-Phe, a stable endproduct of bradykinin metabolism (from cultured rat aortic smooth muscle cells exposed to bradykinin).
Int. Immunopharmacol. 2(13-14) , 1995-2003, (2002) The peptide hormone bradykinin is a mediator in many physiological and pathological processes. The generation and, to a limited extent, metabolism occur at the sites of action. The short half-life of bradykinin (approximately 15 s) renders measurements of its... |