Histatin-5
Histatin-5 structure
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Common Name | Histatin-5 | ||
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| CAS Number | 104339-66-4 | Molecular Weight | 3036.29000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C133H195N51O33 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Salivary histatin 5 induces non-lytic release of ATP from Candida albicans leading to cell death.
J. Biol. Chem. 274 , 18872, (1999) Salivary histatins are potent in vitro antifungal proteins and have promise as therapeutic agents against oral candidiasis. We performed pharmacological studies directed at understanding the biochemical basis of Hst 5 candidacidal activity. Three inhibitors o... |
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Histatin 5 is a substrate and not an inhibitor of the Arg- and Lys-specific proteinases of Porphyromonas gingivalis.
Biochem. Biophys. Res. Commun. 250 , 474, (1998) The salivary peptide histatin 5 has been reported to be an inhibitor of the Arg- and Lys-specific proteinases of Porphyromonas gingivalis, an oral pathogen associated with periodontitis. In this study a purified P. gingivalis proteinase preparation consisting... |
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Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis.
Biochem. Biophys. Res. Commun. 174 , 625, (1991) We examined the effect of histatin 5 from human parotid saliva on various proteases. Histatin 5 strongly inhibited a trypsin-like protease produced by Bacteroides gingivalis with an IC50 value of 55 nM. Clostripain was also inhibited (IC50 = 800 nM). Activiti... |