4-Methylumbelliferyl Sulfate Potassium Salt
4-Methylumbelliferyl Sulfate Potassium Salt structure
|
Common Name | 4-Methylumbelliferyl Sulfate Potassium Salt | ||
|---|---|---|---|---|
| CAS Number | 15220-11-8 | Molecular Weight | 294.32200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H7KO6S | Melting Point | 287-290ºC | |
| MSDS | USA | Flash Point | N/A | |
|
Improving arylsulfatase activity determination in dried blood spots: Screening and diagnostic approaches for Maroteaux-Lamy syndrome (MPS VI).
Clin. Chim. Acta 446 , 86-92, (2015) Mucopolysaccharidosis type VI can be screened by measuring the lysosomal arylsulfatase B (ARSB) residual enzyme activity in dried blood spots (DBS) using synthetic substrates. However, we have found experimental obstacles when determining ARSB activity with t... |
|
|
Identification of sulfation sites of metabolites and prediction of the compounds' biological effects.
Anal. Bioanal. Chem 386(3) , 666-74, (2006) Characterizing the biological effects of metabolic transformations (or biotransformation) is one of the key steps in developing safe and effective pharmaceuticals. Sulfate conjugation, one of the major phase II biotransformations, is the focus of this study. ... |
|
|
Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases.
ChemBioChem. 11(17) , 2393-7, (2010)
|
|
|
Aryl sulfatase from Naja nigricolis venom: characterization and possible contribution in the pathology of snake poisoning.
J. Biochem. Mol. Toxicol. 17 , 59-66, (2003) The venom of Naja nigricolis was found to contain a high level of the enzyme aryl sulfatase. The enzyme was isolated from the venom of N. nigriclois and purified to electrophoretic homogeneity by gel chromatography on Sephadex G-100, DEAE-cellulose, and pheny... |
|
|
Hydrolases in intracellular compartments of rat liver cells. Evidence for selective activation and/or delivery.
J. Biol. Chem. 266(7) , 4341-7, (1991) We used perfused rat livers to investigate the role of endosomes versus lysosomes in the hydrolysis of endocytosed material. When perfusions were performed at 37 degrees C with 125I-asialoorosomucoid, 125I-galactosylated albumin, or 125I-mannosylated albumin,... |
|
|
Pharmacokinetic analysis of factors determining elimination pathways for sulfate and glucuronide metabolites of xenobiotics. III: mechanisms for sinusoidal efflux of 4-methylumbelliferone sulfate.
Xenobiotica 34(5) , 439-48, (2004) 1. To elucidate the mechanisms involved in the sinusoidal efflux of sulfate and glucuronide metabolites of 4-methylumbelliferone (4MU), isolated rat liver perfusion studies were performed under several conditions. 2. The effect of sodium azide on the hepatic ... |
|
|
Differential involvement of Mrp2 (Abcc2) and Bcrp (Abcg2) in biliary excretion of 4-methylumbelliferyl glucuronide and sulfate in the rat.
J. Pharmacol. Exp. Ther. 319(1) , 459-67, (2006) The hepatic excretion of hydrophilic conjugates, end products of phase II metabolism, is not completely understood. In the present studies, transport mechanism(s) responsible for the biliary excretion of 4-methylumbelliferyl glucuronide (4MUG) and 4-methylumb... |
|
|
Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7.
Biochem. Pharmacol. 67(1) , 191-9, (2004) Renal ischaemia is associated with accumulation of fatty acids (FA) and mobilisation of arachidonic acid (AA). Given the capacity of UDP-glucuronosyltransferase (UGT) isoforms to metabolise both drugs and FA, we hypothesised that FA would inhibit renal drug g... |
|
|
Male-pattern baldness in men with X-linked recessive ichthyosis.
Dermatology 200(3) , 247-9, (2000) X-linked recessive ichthyosis (XRI) is a genetic disorder of keratinization with extracutaneous manifestations due to deficiency of steroid sulfatase (STS). Because STS plays an important role in androgen metabolism, and elevated levels of dehydroepiandroster... |
|
|
Fluorometric assay for alcohol sulfotransferase.
Anal. Biochem. 339(1) , 54-60, (2005) A sensitive fluorometric assay was developed for alcohol sulfotransferase (AST). This was the first continuous fluorometric assay reported for AST. It used 3'-phosphoadenosine 5'-phosphosulfate regenerated from 3-phosphoadenosine 5'-phosphate by a recombinant... |