CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC
![CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC Structure](https://image.chemsrc.com/caspic/453/50372-80-0.png)
CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC structure
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Common Name | CAINDEXNAME:8-AZABICYCLO[3.2.1]OCTANE-2-CARBOXYLIC | ||
|---|---|---|---|---|
| CAS Number | 50372-80-0 | Molecular Weight | 409.43000 | |
| Density | 1.099g/cm3 | Boiling Point | 350.2ºC at 760 mmHg | |
| Molecular Formula | C20H27NO8 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 121.3ºC | |
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New, potent cocaine analogs: ligand binding and transport studies in rat striatum.
Eur. J. Pharmacol. 184(2-3) , 329-32, (1990) Two potent cocaine analogs have been developed that have the highest known affinities for the cocaine binding site in rat striatum. Both 3 beta-(4-chlorophenyl)- (RTI-COC-31) and 3 beta-(4-methylphenyl)-tropane-2-carboxylic acid methyl ester (RTI-COC-32) comp... |
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Saturable (3H)cocaine binding in central nervous system of mouse.
Life Sci. 27(12) , 1055-62, (1980)
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Synthesis and transporter binding properties of 2,3-diphenyltropane stereoisomers. Comparison to 3beta-phenyltropane-2beta-carboxylic acid esters.
J. Med. Chem. 40(8) , 1247-51, (1997) 2beta,3beta-Diphenyl-(5), 2alpha,3alpha-diphenyl-(6), and 2alpha,3beta-diphenyltropane (3) as well as 2,3-diphenyltrop-2-ene (4) were prepared in racemic form and assayed for inhibition of radioligand binding at the dopamine (DA), serotonin (5-HT), and norepi... |
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Effect of repeated administration of various doses of cocaine and WIN 35,065-2 on locomotor behavior of mice.
Eur. J. Pharmacol. 130(1-2) , 65-72, (1986) Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg ... |
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Synthesis and ligand binding of eta(6)-(2beta-carbomethoxy-3beta-phenyltropane) transition metal complexes.
J. Med. Chem. 39(7) , 1560-3, (1996) The transition metal complexes [eta(6)- (2beta-carbomethoxy-3beta-phenyltropane)]tricarbonylchromium (3) and [eta(6)-(2beta-carbomethoxy-3beta-phenyltropane)] [eta(5)-(pentamethylcyclopentadienyl)]ruthenium(II)triflate (4) were synthesized from 2beta-carbomet... |
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Development of 3-phenyltropane analogues with high affinity for the dopamine and serotonin transporters and low affinity for the norepinephrine transporter.
J. Med. Chem. 51(24) , 8048-56, (2008) Previous studies showed that the mixed monoamine transporter inhibitor (6, RTI-112) reduced cocaine self-administration at a high level of serotonin transporter (5-HTT) occupancy with no detectable dopamine transporter (DAT) occupancy. In this study, a series... |
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[Pharmacology of troparil].
Farmakol. Toksikol. 48(1) , 15-9, (1985) The physiological action of the tropan derivative troparil (2-beta-methoxycarbonyl-3-beta-phenyltropan or 2-exo-3-exo-2-carbomethoxy-aryltropan was studied. Troparil was demonstrated to be a highly active stimulant of the nervous activity according to a lot o... |
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Cocaine receptors: in vivo labeling with 3H-(-)cocaine, 3H-WIN 35,065-2, and 3H-WIN 35,428.
Synapse 4(4) , 390-2, (1989)
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Repeated injection of GBR 12909, but not cocaine or WIN 35,065-2, into the ventral tegmental area induces behavioral sensitization.
Behav. Brain Res. 97(1-2) , 39-48, (1998) A role for the mesolimbic dopamine system in the development of behavioral sensitization to psychostimulants, such as cocaine and amphetamine, is well established. Previous reports have suggested that the ventral tegmental area (VTA) is involved in the initia... |
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Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropanes.
Bioorg. Med. Chem. Lett. 16(1) , 217-20, (2006) A series of 16 new 2beta-carbomethoxy-3beta-[aryl or heteroaryl]phenyltropane derivatives was synthesized and evaluated for binding to monoamine transporters. Most of the compounds exhibited nanomolar affinity for the serotonin transporter (SERT). Four compou... |