BW A4C
BW A4C structure
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Common Name | BW A4C | ||
|---|---|---|---|---|
| CAS Number | 106328-57-8 | Molecular Weight | 283.32200 | |
| Density | 1.201g/cm3 | Boiling Point | 464.9ºC at 760 mmHg | |
| Molecular Formula | C17H17NO3 | Melting Point | 79.3-80.1ºC(lit.) | |
| MSDS | USA | Flash Point | 235ºC | |
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Effect of polyunsaturated fatty acids on the growth of murine colon adenocarcinomas in vitro and in vivo.
Br. J. Cancer 70(1) , 6-10, (1994) The effect of the polyunsaturated fatty acids (PUFAs) linoleic acid (LA) and arachidonic acid (AA) on the growth of two murine colon adenocarcinoma cell lines (MAC26 and MAC13) has been determined both in vitro and in vivo. When the serum concentrations in th... |
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The 5-lipoxygenase inhibitor BWA4C impairs osteoclastic resorption in a synchronized model of bone remodeling.
Bone 17(2) , 185-91, (1995) The role of leukotrienes on bone resorption was tested in a well-standardized model of bone remodeling by inhibiting their biosynthesis with BWA4C, a specific inhibitor of 5-lipoxygenase. After extraction of their upper molars unilaterally, 30 Wistar rats wer... |
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A test system for leukotriene synthesis inhibitors based on the in-vitro differentiation of the human leukemic cell lines HL-60 and Mono Mac 6.
Naunyn Schmiedebergs Arch. Pharmacol. 356(4) , 441-5, (1997) Differentiation of HL-60 cells along the granulocytic lineage by DMSO in the presence of transforming growth factor-beta and low concentrations of 1,25-dihydroxyvitamin D3 leads to the upregulation of 5-lipoxygenase activity in 100,000 g supernatants and inta... |
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Inhibition of lipoxygenase and cyclooxygenase augments cardiac injury by H2O2
Free Radic. Biol. Med. 15(1) , 27-35, (1993) The role of arachidonic acid metabolites in the cardiac effects of toxic oxygen metabolites (TOM) was investigated in buffer-perfused rat hearts (Langendorff model). Hydrogen peroxide (H 2O 2, 200 μM) was given for 10 min to generate TOM, followed by 30 min r... |
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Effects of a lipoxygenase inhibitor on digoxin-induced cardiac arrhythmias in the isolated perfused guinea-pig heart.
Gen. Pharmacol. 29(5) , 789-92, (1997) 1. The effects of a lipoxygenase inhibitor, BW A4C, on digoxin-induced arrhythmias and cardiac dynamics (contractile force, perfusion pressure, heart rate) were investigated in Langendorff-perfused isolated guinea-pig hearts. In the control group, arrhythmias... |
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Role of lipid hydroperoxides in the activation of 15-lipoxygenase.
Biochemistry 35(22) , 7197-203, (1996) We have used stopped-flow rapid reaction methods, employing both fluorescence and absorbance monitoring, together with HPLC analysis of the products to study the activation of soybean 15-lipoxygenase by 13(S)-hydroperoxy-9, 11(E,Z)-octadecadienoic acid (13-HP... |
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Effects of endogenously produced arachidonic acid metabolites on rat mesangial cell proliferation.
Prostaglandins Leukot. Essent. Fatty Acids 51(3) , 177-82, (1994) The role of endogenously produced arachidonic acid metabolites on glomerulonephritis was investigated using cultured rat mesangial cells. The cultured mesangial cells could produce prostaglandin (PG) E2 and F2 alpha and 12-hydroxyeicosatetraenoic acid (12-HET... |
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Suppression of ovarian oxytocin secretion after intra-luteal administration of the arachidonate 5-lipoxygenase inhibitor BWA4C in the ewe.
Res. Vet. Sci. 64(3) , 263-4, (1998) The effect of an intra-luteal injection of the 5-lipoxygenase (5-LO) inhibitor BWA4C (2 mg in 50 microl DMSO) on the secretion of oxytocin (OT) from the corpus luteum in response to a close-arterial infusion of prostaglandin (PG)-F2alpha (5 ng min(-1)) was ex... |
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Interleukin-1 receptor antagonist displays intrinsic agonist activity on rat gastric fundus motility in vitro.
Eur. J. Pharmacol. 275(1) , 31-7, (1995) It has been shown previously that both forms of interleukin-1, 1 alpha and 1 beta, produce dose-dependent relaxation of the rat gastric fundus in vitro, accompanied by an increased production and release of eicosanoids. This effect appears to be mediated, at ... |
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Inhibition by unsaturated fatty acids of type II secretory phospholipase A2 synthesis in guinea-pig alveolar macrophages evidence for the eicosanoid-independent pathway.
Eur. J. Biochem. 267(12) , 3633-9, (2000) The effect of arachidonic acid (C20:4) on the production of secretory type II phospholipase A2 (sPLA2-II) by guinea-pig alveolar macrophages was investigated. We show that incubation of these cells with 1-30 microM of arachidonic acid inhibits the synthesis o... |