2-(3-Bromophenyl)-1,3-dioxolane

2-(3-Bromophenyl)-1,3-dioxolane Structure
2-(3-Bromophenyl)-1,3-dioxolane structure
Common Name 2-(3-Bromophenyl)-1,3-dioxolane
CAS Number 17789-14-9 Molecular Weight 229.071
Density 1.5±0.1 g/cm3 Boiling Point 278.5±0.0 °C at 760 mmHg
Molecular Formula C9H9BrO2 Melting Point N/A
MSDS Chinese USA Flash Point 130.3±21.4 °C

Delta agonist hydroxy bioisosteres: the discovery of 3-((1-benzylpiperidin-4-yl){4-[(diethylamino)carbonyl]phenyl}amino)benzamide with improved delta agonist activity and in vitro metabolic stability.

Bioorg. Med. Chem. Lett. 19(21) , 5999-6003, (2009)

We have investigated phenol replacements in a series of diaryl amino piperidine delta opioid agonists. From this study we have demonstrated that the hydroxy functional group can be replaced with a primary amide group, giving enhanced activity at the delta rec...