Idebenone
Idebenone structure
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Common Name | Idebenone | ||
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| CAS Number | 58186-27-9 | Molecular Weight | 338.439 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 497.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C19H30O5 | Melting Point | 52-550C | |
| MSDS | Chinese USA | Flash Point | 170.1±22.2 °C | |
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2-deoxy-D-glucose enhances anesthetic effects in mice.
Anesth. Analg. 120(2) , 312-9, (2015) The mechanisms of general anesthesia by volatile drugs remain largely unknown. Mitochondrial dysfunction and reduction in energy levels have been suggested to be associated with general anesthesia status. 2-Deoxy-D-glucose (2-DG), an analog of glucose, inhibi... |
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Idebenone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in age-related cognitive disorders.
Drugs Aging 5(2) , 133-52, (1994) Idebenone is a benzoquinone compound which has been investigated in elderly patients with dementia. Its precise mechanism(s) of action remains unknown, but in vitro and in vivo studies suggest the drug may diminish nerve cell damage due to ischaemia, correct ... |
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Idebenone: an emerging therapy for Friedreich ataxia.
J. Neurol. 256 Suppl 1 , 25-30, (2009) This paper reviews the history and pre-clinical development of idebenone and summarises the results of clinical studies, published from 1999 to 2008, on the use of idebenone in the treatment of patients with Friedreich ataxia (FRDA). As a benzoquinone that ca... |
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Pharmacokinetic evaluation of idebenone.
Expert Opin. Drug Metab. Toxicol. 6(11) , 1437-44, (2010) Idebenone is a synthetic short chain benzoquinone that acts as an electron carrier in the mitochondrial electron transport chain, thereby, facilitating the production of ATP. In addition, idebenone is an antioxidant and can inhibit lipid peroxidation and may ... |
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[The use of idebenone (noben) in neurological practice].
Zh. Nevrol. Psikhiatr. Im. S. S. Korsakova 106(11) , 66-71, (2006)
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Idebenone - monograph.
Altern. Med. Rev. 6(1) , 83-6, (2001)
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Idebenone in Friedreich's ataxia.
Expert Opin. Pharmacother. 9(13) , 2327-37, (2008) Friedreich's ataxia is an autosomal recessive neurodegenerative disease where impaired mitochondrial function and excessive production of free radicals play a central pathogenetic role. Idebenone, a synthetic analogue of coenzyme Q, is a powerful antioxidant ... |
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Co-enzyme Q10 and idebenone use in Friedreich's ataxia.
J. Neurochem. 126 Suppl 1 , 125-41, (2013) Friedreich's ataxia is a debilitating progressive neurodegenerative disease associated with cardiomyopathy and other features. The underlying cause is a deficiency of the mitochondrial protein frataxin which causes mitochondrial iron deposition, increased oxi... |
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Clinical experience with high-dose idebenone in Friedreich ataxia.
J. Neurol. 256 Suppl 1 , 42-5, (2009) Several reports in the literature describe the effects of low-dose (5 mg/kg/day) idebenone in significantly reducing cardiac hypertrophy in patients with Friedreich ataxia. However, the effects of idebenone on neurological function have not been reliably dete... |
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Coenzyme Q(10) and idebenone in the therapy of respiratory chain diseases: rationale and comparative benefits.
Mol. Genet. Metab. 77(1-2) , 21-30, (2002) While there have been major advances in both the identification of the molecular basis and our understanding of mitochondrial pathology, the clinical management of patients with mitochondrial respiratory chain disease is still essentially supportive. Quinones... |