glucagonTFA
glucagonTFA structure
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Common Name | glucagonTFA | ||
|---|---|---|---|---|
| CAS Number | 16941-32-5 | Molecular Weight | 3482.747 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C153H225N43O49S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Over-expression of Follistatin-like 3 attenuates fat accumulation and improves insulin sensitivity in mice.
Metab. Clin. Exp. 64(2) , 283-95, (2015) Follistatin-like 3 (fstl3), a natural inhibitor of members of the TGF-β family, increases during resistance training in human plasma. Fstl3 primarily binds myostatin and activin A, and thereby inhibits their functions. We hypothesize that blocking myostatin a... |
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Progenitor potential of nkx6.1-expressing cells throughout zebrafish life and during beta cell regeneration.
BMC Biol. 13 , 70, (2015) In contrast to mammals, the zebrafish has the remarkable capacity to regenerate its pancreatic beta cells very efficiently. Understanding the mechanisms of regeneration in the zebrafish and the differences with mammals will be fundamental to discovering molec... |
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Co-expression of the homologous proteases fibroblast activation protein and dipeptidyl peptidase-IV in the adult human Langerhans islets.
Histochem. Cell Biol. 143(5) , 497-504, (2015) Fibroblast activation protein (FAP, seprase, EC 3.4.21.B28) and dipeptidyl peptidase-IV (DPP-IV, CD26, EC 3.4.14.5) are homologous serine proteases implicated in the modulation of the bioavailability and thus the function of a number of biologically active pe... |
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Differential levels of Neurod establish zebrafish endocrine pancreas cell fates.
Dev. Biol. 402 , 81-97, (2015) During development a network of transcription factors functions to differentiate foregut cells into pancreatic endocrine cells. Differentiation of appropriate numbers of each hormone-expressing endocrine cell type is essential for the normal development of th... |
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Potential of UCHL1 as biomarker for destruction of pancreatic beta cells.
J. Proteomics 117 , 156-67, (2015) There is a clinical need for plasma tests for real-time detection of beta cell destruction, as surrogate endpoint in islet transplantation and immunoprevention trials in type 1 diabetes. This study reports on the use of label-free LC-MS/MS proteomics for bott... |
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Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.
PLoS ONE 9(11) , e112109, (2014) We have generated a novel monoclonal antibody targeting human FGFR1c (R1c mAb) that caused profound body weight and body fat loss in diet-induced obese mice due to decreased food intake (with energy expenditure unaltered), in turn improving glucose control. R... |
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Complement inhibitor CD55 governs the integrity of membrane rafts in pancreatic beta cells, but plays no role in insulin secretion.
Biochem. Biophys. Res. Commun. 460 , 518-24, (2015) CD55 is a glycosylphosphatidylinositol-anchored protein, which inhibits complement activation by acting on the complement C3 convertases. CD55 is widely localized in the cholesterol rich regions of the cell plasma membrane termed membrane rafts. CD55 is attac... |
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Effect of propylene glycol on adipose tissue mobilization in postpartum over-conditioned Holstein cows.
J. Dairy Sci. 98 , 8581-96, (2015) Our objective was to investigate the quantitative and qualitative effects of propylene glycol (PG) allocation on postpartum adipose tissue mobilization in over-conditioned Holstein cows. Nine ruminally cannulated and arterially catheterized cows were, at part... |
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Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance.
Biol. Open 4 , 1367-75, (2015) Tryptophan metabolites have been linked in observational studies with type 2 diabetes, cognitive disorders, inflammation and immune system regulation. A rate-limiting enzyme in tryptophan conversion is arylformamidase (Afmid), and a double knockout of this ge... |
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Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation.
Mol. Cell. Endocrinol. 399 , 296-310, (2014) Heparan sulphate proteoglycans (HSPGs) exist in pancreatic beta cells, and HS seems to modulate important interactions in the islet microenvironment. However, the intra-islet structures of HS in health or altered glucose homeostasis are currently unknown. Her... |