2'-Deoxyinosine
2'-Deoxyinosine structure
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Common Name | 2'-Deoxyinosine | ||
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| CAS Number | 890-38-0 | Molecular Weight | 252.227 | |
| Density | 1.9±0.1 g/cm3 | Boiling Point | 620.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C10H12N4O4 | Melting Point | 250 °C | |
| MSDS | USA | Flash Point | 329.1±34.3 °C | |
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Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.
J. Chromatogr. A. 1356 , 197-210, (2014) Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved understanding of the absorption and intermediary metabolism ... |
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Preparation and evaluation of a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid.
J. Chromatogr. A. 1375 , 101-9, (2014) To develop a novel hybrid monolithic column based on pentafluorobenzyl imidazolium bromide ionic liquid, a new ionic liquid monomer was synthesized from 1-vinylimidazole and pentafluorobenzyl bromide. By employing a facile one-step copolymerization of polyhed... |
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Comparative characterization of nucleotides, nucleosides and nucleobases in Abelmoschus manihot roots, stems, leaves and flowers during different growth periods by UPLC-TQ-MS/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 1006 , 130-7, (2015) Nucleotides, nucleosides and nucleobases have been proven as important bioactive compounds related to many physiological processes. Abelmoschus manihot (L.) Medicus from the family of Malvaceae is an annual herbal plant of folk medicine widely distributed in ... |
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Biodistribution, tumor uptake and efficacy of 5-FU-loaded liposomes: why size matters.
Pharm. Res. 31(10) , 2677-84, (2014) We have investigated the impact of particle size on the biodistribution, tumor uptake and antiproliferative efficacy of 5-FU-loaded liposomes.Three different batches of pegylated liposomes varying in size (i.e., 70, 120 and 250 nm respectively) were tested. T... |
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Measurement of deoxyinosine adduct: Can it be a reliable tool to assess oxidative or nitrosative DNA damage?
Toxicol. Lett. 214(2) , 226-33, (2012) Adenosine deaminases (ADA) are key enzymes that deaminate adenosine (A) or deoxyadenosine (dA) and produce inosine or deoxyinosine (dI), respectively. While ADA only deaminates free dA, reactive nitrogen species (RNS) or reactive oxygen species (ROS) deaminat... |
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O6-(benzotriazol-1-yl)inosine derivatives for C6 modification of purine nucleosides.
Curr. Protoc. Nucleic Acid Chem. Chapter 1 , Unit 1.22, (2009) A new class of reactive nucleosides, O(6)-(benzotriazol-1-yl) derivatives of inosine and 2'-deoxyinosine, have been developed via reaction of silyl-protected or unprotected inosine and 2'-deoxyinosine with 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphoniu... |
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Mutation identification DNA analysis system (MIDAS) for detection of known mutations.
Electrophoresis 20(6) , 1141-8, (1999) We introduce a novel experimental strategy for DNA mutation detection named the Mismatch Identification DNA Analysis System (MIDAS) [1, 2], which has an associated isothermal probe amplification step to increase target DNA detection sensitivity to attomole le... |
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Endonuclease V-assisted accurate cleavage of oligonucleotide probes controlled by deoxyinosine and deoxynucleoside phosphorothioate for sequencing-by-ligation.
Analyst 137(19) , 4421-4, (2012) Sequencing-by-ligation (SBL) is one of the next-generation sequencing methods for massive parallel sequencing. The ligated probes used in SBL should be accurately cleaved for a better ligation in the next cycle. Here, a novel kind of oligonucleotide probe tha... |
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Synthesis and reactions of 2-chloro- and 2-tosyloxy-2'-deoxyinosine derivatives.
J. Org. Chem. 70(18) , 7188-95, (2005) Convenient syntheses of 2-chloro- and 2-tosyloxy-2'-deoxyinosine as their tert-butyldimethylsilyl ethers are described. Both compounds can be synthesized via a common route and rely on commercially available 2'-deoxyguanosine. The present method leading to th... |
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Sequencing by ligation variation with endonuclease V digestion and deoxyinosine-containing query oligonucleotides.
BMC Genomics 12 , 598, (2011) Sequencing-by-ligation (SBL) is one of several next-generation sequencing methods that has been developed for massive sequencing of DNA immobilized on arrayed beads (or other clonal amplicons). SBL has the advantage of being easy to implement and accessible t... |