Barasertib (AZD1152-HQPA)
Barasertib (AZD1152-HQPA) structure
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Common Name | Barasertib (AZD1152-HQPA) | ||
|---|---|---|---|---|
| CAS Number | 722544-51-6 | Molecular Weight | 507.560 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 796.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C26H30FN7O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 435.6±32.9 °C | |
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MicroRNA let-7b regulates genomic balance by targeting Aurora B kinase.
Mol. Oncol. 9 , 1056-70, (2015) The let-7 microRNA (miRNA) family has been implicated in the regulation of diverse cellular processes and disease pathogenesis. In cancer, loss-of-function of let-7 miRNAs has been linked to tumorigenesis via increased expression of target oncogenes. Excessiv... |
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The novel function of JADE1S in cytokinesis of epithelial cells.
Cell Cycle 14 , 2821-34, (2015) JADE1 belongs to a small family of PHD zinc finger proteins that interacts with histone acetyl transferase (HAT) HBO1 and is associated with chromatin. We recently reported JADE1 chromatin shuttling and phosphorylation during G2/M to G1 transition, which was ... |
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Inhibitor of Aurora Kinase B Induces Differentially Cell Death and Polyploidy via DNA Damage Response Pathways in Neurological Malignancy: Shedding New Light on the Challenge of Resistance to AZD1152-HQPA.
Mol. Neurobiol. 53 , 1808-23, (2016) Aurora kinase B (AURKB), a crucial regulator of malignant mitosis, is involved in chromosome segregation and cytokinesis. AZD1152-HQPA is a selective inhibitor for AURKB activity and currently bears clinical assessment for several malignancies. However, the e... |
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AZD1152-HQPA induces growth arrest and apoptosis in androgen-dependent prostate cancer cell line (LNCaP) via producing aneugenic micronuclei and polyploidy.
Tumour Biol. 36(2) , 623-32, (2015) Prostate cancer is the frequent non-cutaneous tumor with high mortality in men. Prostate tumors contain cells with different status of androgen receptor. Androgen receptor plays important roles in progression and treatment of prostate cancer. Aurora B kinase,... |