Miglitol
Miglitol structure
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Common Name | Miglitol | ||
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| CAS Number | 72432-03-2 | Molecular Weight | 207.224 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 453.7±45.0 °C at 760 mmHg | |
| Molecular Formula | C8H17NO5 | Melting Point | 114ºC | |
| MSDS | USA | Flash Point | 284.3±27.4 °C | |
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Specificity of Processing α-glucosidase I is guided by the substrate conformation: crystallographic and in silico studies.
J. Biol. Chem. 288(19) , 13563-74, (2013) The enzyme “GluI” is key to the synthesis of critical glycoproteins in the cell.We have determined the structure of GluI, and modeled binding with its unique sugar substrate.The specificity of this interaction derives from a unique conformation of the substra... |
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Study of the inhibition of two human maltase-glucoamylases catalytic domains by different α-glucosidase inhibitors.
Carbohydr. Res. 346(17) , 2688-92, (2011) In humans, both the N-terminal catalytic domain (NtMGAM) and the C-terminal catalytic domain (CtMGAM) of small intestinal maltase glucoamylase (MGAM) are α-glycosidases that catalyze the hydrolysis of α-(1→4) glycosidic linkages in the process of starch diges... |
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Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlleddb/dbmice
Biochem. Biophys. Res. Commun. 440(4) , 570-5, (2013) • Beneficial effects of combination therapy with vildagliptin plus miglitol on glucose tolerance of db/db mice were evaluated. • Postprandial glucose- and incretin response was normalized by the combination therapy. • Diabetes onset of db/db mice was prevente... |
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Intestinal alpha-glucosidase inhibitors: abdominal gas cysts.
Prescrire Int. 21(130) , 212-3, (2012) Detailed imaging studies of gas cysts in the intestinal mucosa (pneumatosis cystoides intestinalis) have been reported in around 20 patients taking acarbose, miglitolor voglibose, i.e. intestinal alpha-glucosidase inhibitors used as hypoglycaemic agents. Almo... |
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The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice.
Metab. Clin. Exp. 62(5) , 734-42, (2013) Alpha-glucosidase inhibitors (α-GIs) show various anti-diabetic or anti-obesity effects in addition to the suppression of postprandial hyperglycemia. Based on recent observations that bile acids (BAs) are involved in glucose and energy homeostasis, we examine... |
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Successful treatment of reactive hypoglycemia secondary to late dumping syndrome using miglitol.
Intern. Med. 51(18) , 2581-5, (2012) We herein describe a 59-year-old woman who had undergone a total gastrectomy for gastric carcinoma and suffered from postprandial hypoglycemia characterized by a loss of consciousness and spasms. She was diagnosed with reactive hypoglycemia and treated with n... |
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Miglitol, an anti-diabetic drug, inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase.
J. Pharmacol. Sci. 120(2) , 121-8, (2012) Endothelial dysfunction caused by oxidative stress plays a key role in atherogenesis. This study investigated whether the anti-diabetic drug miglitol, an α-glucosidase inhibitor, which is currently available in clinical practice, can prevent endothelial cell ... |
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Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50.
Diabetes Technol. Ther. 14(7) , 545-51, (2012) The additive effect of α-glucosidase inhibitors (α-GIs) was investigated in patients with type 2 diabetes (T2D) under control with rapid-acting insulin analog.Thirty-six poorly controlled T2D patients were recruited, and plasma glucose (PG) was controlled by ... |
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Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients.
Diabetes Obes. Metab. 14(3) , 283-7, (2012) To compare the effects of miglitol [an alpha-glucosidase inhibitor (AGI) absorbed in the intestine] and voglibose (an AGI not absorbed) on plasma glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP) levels, 26 and 24 Japanese type 2 diabet... |
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Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation.
Diab. Vasc. Dis. Res. 9(3) , 163-9, (2012) Alpha-glucosidase inhibitors have been available for clinical use for about 20 years. They have shown reasonably good efficacy comparable to other oral blood glucose lowering drugs and in some parts of the world are the most commonly prescribed oral diabetes ... |