Bexarotene
Bexarotene structure
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Common Name | Bexarotene | ||
|---|---|---|---|---|
| CAS Number | 153559-49-0 | Molecular Weight | 348.478 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 489.7±44.0 °C at 760 mmHg | |
| Molecular Formula | C24H28O2 | Melting Point | 230-231ºC | |
| MSDS | Chinese USA | Flash Point | 229.5±23.1 °C | |
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Retinoids Bias Integrin Expression and Function in Cutaneous T-Cell Lymphoma.
J. Invest. Dermatol. 135 , 2102-8, (2015) Cutaneous T-cell lymphoma (CTCL) is a heterogeneous group of malignancies characterized by accumulation of malignant T-cells within the skin. Retinoids, metabolic derivatives, and synthetic analogs of vitamin A embody an effective CTCL therapy with over three... |
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RNA-sequencing reveals transcriptional up-regulation of Trem2 in response to bexarotene treatment.
Neurobiol. Dis. 82 , 132-40, (2015) We have recently demonstrated that short term bexarotene treatment of APP/PS1 mice significantly improves their cognitive performance. While there were no changes in plaque load, or insoluble Aβ levels in brain, biochemical analysis strongly suggested improve... |
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Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling.
J. Clin. Invest. 125(2) , 809-23, (2015) Osteoclasts are bone-resorbing cells that are important for maintenance of bone remodeling and mineral homeostasis. Regulation of osteoclast differentiation and activity is important for the pathogenesis and treatment of diseases associated with bone loss. He... |
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Bexarotene reduces blood-brain barrier permeability in cerebral ischemia-reperfusion injured rats.
PLoS ONE 10(4) , e0122744, (2015) Matrix metalloproteinase-9 (MMP-9) over-expression disrupts the blood-brain barrier (BBB) in the ischemic brain. The retinoid X receptor agonist bexarotene suppresses MMP-9 expression in endothelial cells and displays neuroprotective effects. Therefore, we hy... |
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Pituitary specific retinoid-X receptor ligand interactions with thyroid hormone receptor signaling revealed by high throughput reporter and endogenous gene responses.
Toxicol. In Vitro 29 , 1609-18, (2015) Disruption of thyroid hormone (TH) signaling can compromise vital processes both during development and in the adult. We previously reported on high-throughput screening experiments for man-made TH disruptors using a stably integrated line of rat pituitary ce... |
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Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells.
Mol. Pharmacol. 86(5) , 570-9, (2014) The retinoid X receptor (RXR) partners with numerous nuclear receptors, such as the peroxisome proliferator activated receptor (PPAR) family, liver X receptors (LXRs), and farnesoid X receptor (FXR). Although each heterodimer can be activated by specific liga... |
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Retinoic Acid Signaling Regulates Differential Expression of the Tandemly-Duplicated Long Wavelength-Sensitive Cone Opsin Genes in Zebrafish.
PLoS Genet. 11 , e1005483, (2015) The signaling molecule retinoic acid (RA) regulates rod and cone photoreceptor fate, differentiation, and survival. Here we elucidate the role of RA in differential regulation of the tandemly-duplicated long wavelength-sensitive (LWS) cone opsin genes. Zebraf... |
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Retinoid X receptor agonists inhibit hypertension-induced myocardial hypertrophy by modulating LKB1/AMPK/p70S6K signaling pathway.
Am. J. Hypertens. 27(8) , 1112-24, (2014) Retinoid X receptor (RXR) has been demonstrated to play an important role in cardiac development and has been implicated in cardiovascular diseases. This study aimed to examine the effects of RXRα agonist bexarotene on pathological left ventricular hypertroph... |
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Distinct functional modes of SUMOylation for retinoid X receptor alpha
Biochem. Biophys. Res. Commun. 464 , 195-200, (2015) The present study investigated human retinoid X receptor alpha (hRXRα) as a substrate for modification with small ubiquitin like modifier (SUMO) and how members of the protein inhibitor of activated STAT (PIAS) family may impact upon this process. In agreemen... |
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Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach.
Oncotarget 6 , 9740-55, (2015) Retinoid X receptor (RXR) and Histone deacetylase (HDAC) are considered important targets for cancer therapy due to their crucial roles in genetic or epigenetic regulations of cancer development and progression. Here, we evaluated the potential of dual target... |