Cycloastragenol
Cycloastragenol structure
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Common Name | Cycloastragenol | ||
|---|---|---|---|---|
| CAS Number | 78574-94-4 | Molecular Weight | 490.715 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 617.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C30H50O5 | Melting Point | 241.0 to 245.0 °C | |
| MSDS | Chinese USA | Flash Point | 327.1±31.5 °C | |
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Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management.
Neurosignals 22(1) , 52-63, (2014) Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity and cell... |
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A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis.
PLoS ONE 8(3) , e58423, (2013) The emergence of diseases associated with telomere dysfunction, including AIDS, aplastic anemia and pulmonary fibrosis, has bolstered interest in telomerase activators. We report identification of a new small molecule activator, GRN510, with activity ex vivo ... |
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Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.
J. Immunol. 181(10) , 7400-6, (2008) Telomerase reverse transcribes telomere DNA onto the ends of linear chromosomes and retards cellular aging. In contrast to most normal somatic cells, which show little or no telomerase activity, immune cells up-regulate telomerase in concert with activation. ... |