Triptolide
Triptolide structure
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Common Name | Triptolide | ||
|---|---|---|---|---|
| CAS Number | 38748-32-2 | Molecular Weight | 360.401 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 601.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H24O6 | Melting Point | 226-227°C | |
| MSDS | USA | Flash Point | 220.7±25.0 °C | |
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Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.
Molecules 17(9) , 11113-23, (2012) The commercial preparation named “Tripterygium glycosides” prepared by column chromatography has been used for the treatment of inflammatory and autoimmune diseases with significant efficacy but concurrent toxicity. The aim of this study was to reduce the tox... |
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Condensin targets and reduces unwound DNA structures associated with transcription in mitotic chromosome condensation.
Nat. Commun. 6 , 7815, (2015) Chromosome condensation is a hallmark of mitosis in eukaryotes and is a prerequisite for faithful segregation of genetic material to daughter cells. Here we show that condensin, which is essential for assembling condensed chromosomes, helps to preclude the de... |
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Cardiosphere-derived cells from pediatric end-stage heart failure patients have enhanced functional activity due to the heat shock response regulating the secretome.
Stem Cells 33(4) , 1213-29, (2015) We have demonstrated that human neonatal cardiosphere-derived cells (CDCs) derived from the young are more regenerative due to their robust secretome. However, it is unclear how the decompensated pediatric heart impacts the functional activity of their CDCs. ... |
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Male contraception: history and development.
Urol. Clin. North Am. 41(1) , 145-61, (2014) Although the twentieth century has seen great strides in the development of female contraception, not a single new agent has been introduced as an approved method for common use for male contraception. Condoms (considered uncomfortable by some) and vasectomy ... |
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RNA polymerase II pausing can be retained or acquired during activation of genes involved in the epithelial to mesenchymal transition.
Nucleic Acids Res. 43 , 3938-49, (2015) Promoter-proximal RNA polymerase II (Pol II) pausing is implicated in the regulation of gene transcription. However, the mechanisms of pausing including its dynamics during transcriptional responses remain to be fully understood. We performed global analysis ... |
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N-acetyl cysteine improves the effects of corticosteroids in a mouse model of chlorine-induced acute lung injury.
Toxicology 328 , 40-7, (2015) Chlorine (Cl2) causes tissue damage and a neutrophilic inflammatory response in the airways manifested by pronounced airway hyperreactivity (AHR). The importance of early anti-inflammatory treatment has previously been addressed. In the previous study, both h... |
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The Inhibition by Oxaliplatin, a Platinum-Based Anti-Neoplastic Agent, of the Activity of Intermediate-Conductance Ca²⁺-Activated K⁺ Channels in Human Glioma Cells.
Cell Physiol. Biochem. 37 , 1390-406, (2015) Oxaliplatin (OXAL) is a third-generation organoplatinum which is effective against advanced cancer cells including glioma cells. How this agent and other related compounds interacts with ion channels in glioma cells is poorly understood. OXAL (100 µM) suppres... |
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Sorafenib and triptolide as combination therapy for hepatocellular carcinoma.
Surgery 156(2) , 270-9, (2014) Sorafenib is the only drug approved by the Food and Drug Administration for metastatic hepatocellular carcinoma (HCC). Triptolide, a diterpene triepoxide, exhibits antineoplastic properties in multiple tumor cell types. In this study, we examined the effects ... |
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Absorption and Metabolism Characteristics of Triptolide as Determined by a Sensitive and Reliable LC-MS/MS Method.
Molecules 20 , 8928-40, (2015) In this research, a sensitive and reliable LC-MS/MS method was developed and applied to determine the concentration of triptolide in rat plasma, microsomes, and cell incubation media. The absolute oral bioavailability of triptolide is 63.9% at a dose of 1 mg·... |
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Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses.
J. Biol. Chem. 290 , 15030-41, (2015) Elongin A performs dual functions in cells as a component of RNA polymerase II (Pol II) transcription elongation factor Elongin and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase that has been shown to target Pol II stalled at sites... |