Thr2-Cyclosporine
Thr2-Cyclosporine structure
|
Common Name | Thr2-Cyclosporine | ||
|---|---|---|---|---|
| CAS Number | 59787-61-0 | Molecular Weight | 1218.611 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 1316.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C62H111N11O13 | Melting Point | 152-155ºC | |
| MSDS | USA | Flash Point | 749.7±34.3 °C | |
|
Comparison of the properties of the CsA analogs monoacetyl CyC (o-acetyl-threonine2 cyclosporin) and methyl-alanyl CsA (N-methyl-L-alanyl6 cyclosporin); monoacetyl cyclosporin is immunosuppressive without binding to cyclophilin.
Clin. Exp. Immunol. 89(1) , 136-42, (1992) Cyclosporin (CsA) is an immunosuppressant which binds to cyclophilin (Cyp). The relationship between Cyp binding and immunosuppression has been questioned since one of the analogs of CsA, N-methyl-L-alanyl6 cyclosporin (methyl-alanyl CsA) binds to Cyp but is ... |
|
|
Tachykinin antagonists screening from microbial origin.
J. Antibiot. 49(1) , 110-2, (1996)
|
|
|
Monitoring cyclosporine by HPLC with cyclosporin C as internal standard.
Clin. Chem. 39(1) , 168, (1993)
|
|
|
Use of 125I-labeled-histamine-cyclosporin C for monitoring serum cyclosporine concentrations in transplantation patients.
Clin. Chem. 32(3) , 492-5, (1986) We synthesized an 125I-labeled-histamine-cyclosporin C tracer, to obviate the use of tritiated tracer in radioimmunoassay of cyclosporine. With this tracer, the assay results varied linearly with concentration up to at least 800 micrograms/L. The within-assay... |
|
|
Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors.
J. Heart Lung Transplant. 22(7) , 715-22, (2003) Cyclosporin (CsA) dose selection is complicated by significant pharmacokinetic variability between patients. Although therapeutic drug monitoring (TDM) has proven to be a useful tool for dose individualization, the search for an effective and practical measur... |
|
|
Experimental pulmonary eosinophilia in mice by Ascaris suum extract.
Am. Rev. Respir. Dis. 141(5 Pt 1) , 1289-95, (1990) The transnasal administration of an extract of the parasite Ascaris suum (Asc) to C57BL/6 mice for 3 wk produced marked eosinophilia in the bronchoalveolar lavage (BAL) fluid. This pulmonary eosinophilia was not accompanied by blood eosinophilia. The oral adm... |
|
|
Pseudoprolines (psiPro) in drug design: direct insertion of psiPro systems into cyclosporin C.
Chemistry 6(23) , 4358-63, (2000) The insertion of acetals that exhibit variable structural features into complex peptides such as cyclosporin C (CsC) results in oxazolidine derivatives (pseudoprolines, psiPro) of tailored physico-chemical and biological properties. N,O-Acetalation of the 2-t... |
|
|
Experimental murine hyalohyphomycosis with soil-derived isolates of Fusarium solani.
Med. Mycol 41(3) , 241-7, (2003) Two strains of soil-borne Fusarium solani, both characterized for their ability to produce cyclosporin A and C, were examined for their pathogenicity in severe combined immunodeficiency (SCID) and BALB/c male mice. Intravenous (i.v.) infections with F. solani... |
|
|
Antimalarial activity of cyclosporins A, C and D.
Afr. J. Med. Med. Sci. 23(1) , 47-51, (1994) Cyclosporin A (CsA) is an immunosuppressive drug widely used in organ transplants. It is also accumulated by the erythrocyte, a site that accommodates one of the stages of malaria parasite. We observe that CsA and its less potent immunosuppressive analogues C... |
|
|
[Effect of P-glycoprotein on the absorption of buagafuran in rat intestinal lumen].
Yao Xue Xue Bao 43(4) , 361-5, (2008) To study the effect of P-glycoprotein (P-gp) on the absorption of buagafuran in ileum, the concentration of buagafuran in Caco-2 cells, rat averted intestinal sacs and recirculating perfusion were determined by UV-HPLC method. Verapamil and cyclospirin A (CsA... |