Heptakis(2,6-di-O-methyl)-b-cyclodextrin
Heptakis(2,6-di-O-methyl)-b-cyclodextrin structure
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Common Name | Heptakis(2,6-di-O-methyl)-b-cyclodextrin | ||
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| CAS Number | 51166-71-3 | Molecular Weight | 1331.356 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1203.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C56H98O35 | Melting Point | 298 - 310ºC | |
| MSDS | Chinese USA | Flash Point | 681.7±34.3 °C | |
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Evaluation of the separation mechanism of electrokinetic chromatography with a microemulsion and cyclodextrins using NMR and molecular modeling.
Electrophoresis 32(21) , 3062-9, (2011) Electrokinetic chromatography (EKC) allows the separation of closely related substances by the detection of fine effects in analyte-separation system interactions. With the goal of understanding the fine effects involved in separation using a dual cyclodextri... |
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Synthesis, cytotoxicity, and phase-solubility study of cyclodextrin click clusters.
J. Pharm. Sci. 103(10) , 3183-9, (2014) To explore the possibility of cyclodextrin click clusters (CCCs) as a new cyclodextrin-based excipient, we prepared three different CCCs; heptakis{6-(4-hydroxymethyl-1H-[1,2,3]triazol-1-yl)-6-deoxy}-β-cyclodextrin (HT-β-CD), heptakis{6-(4-hydroxymethyl-1H-[1,... |
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Host-guest interaction between new nitrooxoisoaporphine and β-cyclodextrins: synthesis, electrochemical, electron spin resonance and molecular modeling studies.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 102 , 226-34, (2013) A new nitrooxoisoaporphine derivative was synthetized and characterized by cyclic voltammetry and electron spin resonance. Its aqueous solubility was improved by complexes formation with β-cyclodextrin, heptakis(2,6-di-O-methyl)-β-cyclodextrin and (2-hydroxyp... |
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Complexation and full characterization of the tretinoin and dimethyl-β-cyclodextrin complex.
AAPS PharmSciTech 12(2) , 553-63, (2011) The aim of this work is to prepare tretinoin/dimethyl-beta-cyclodextrin complexes and fully characterize them through various analytical techniques. According to the phase solubility studies performed, the equilibrium for maximum complexation is reached in ab... |
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Methods for determination of all binding parameters in systems with simultaneous borate and cyclodextrin complexation.
J. Chromatogr. A. 1218(40) , 7211-8, (2011) Two novel methods for determination of binding constants in the systems with borate and cyclodextrin complexation were developed. The methods enable to determine all binding parameters in these systems and even the binding constants of interaction of a neutra... |
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Enhancement of oral bioavailability of cilostazol by forming its inclusion complexes.
AAPS PharmSciTech 10(2) , 660-9, (2009) The study was designed to investigate the effect of cyclodextrins (CDs) on the solubility, dissolution rate, and bioavailability of cilostazol by forming inclusion complexes. Natural CDs like beta-CD, gamma-CD, and the hydrophilic beta-CD derivatives, DM-beta... |
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Gas phase isomeric differentiation of oleanolic and ursolic acids associated with heptakis-(2,6-di-O-methyl)-beta-cyclodextrin by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.
J. Mass Spectrom. 45(4) , 444-50, (2010) Oleanolic acid (OA) and ursolic acid (UA) are isomeric triterpenoid compounds with similar pharmaceutical properties. Usually, modern chromatographic and electrophoretic methods are widely utilized to differentiate these two compounds. Compared with mass spec... |
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Formulation and evaluation of thienorphine hydrochloride sublingual delivery system.
Chem. Pharm. Bull. 60(12) , 1479-86, (2012) Thienorphine hydrochloride (ThH) is a highly insoluble and readily metabolized partial-opioid agonist. It is used for the treatment of pain and heroin addiction. This study aimed to formulate and evaluate sublingual delivery systems containing ThH. Dimethyl-β... |
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Investigation of liposome formulation effects on rivastigmine transport through human colonic adenocarcinoma cell line (CACO-2).
Pharmazie 65(1) , 32-40, (2010) Transportations of rivastigmine containing liposomes across Caco-2 cells were studied and in vitro test results were compared with in vivo results. MTT test was used for cell viability studies. Series of formulations were prepared containing rivastigmine whic... |
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Transport evaluation of alendronate across Caco-2 cell monolayers.
Pharmazie 64(2) , 98-103, (2009) The transport of alendronate through Caco-2 monolayers in the absence and presence of absorption enhancers (sodium taurocholate-STC and dimethyl-beta-cyclodextrin-DM-beta-CD) was studied. The viability of Caco-2 cells was determined by MTT assay. The effects ... |