2,3-Dihydrophthalazine-1,4-dione
2,3-Dihydrophthalazine-1,4-dione structure
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Common Name | 2,3-Dihydrophthalazine-1,4-dione | ||
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| CAS Number | 1445-69-8 | Molecular Weight | 162.145 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 523.5ºC at 760 mmHg | |
| Molecular Formula | C8H6N2O2 | Melting Point | >300 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 270.4ºC | |
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Effects of 2,3-dihydrophthalazine-1,4-dione on Sprague Dawley rats lipid metabolism and serum lipoproteins.
Biomed. Biochim. Acta 47(4-5) , 423-33, (1988) 2,3-Dihydrophthalazine-1,4-dione effectively lowers serum levels of cholesterol and triglycerides in Sprague Dawley rats after two weeks, after which the cholesterol levels continued to decline. The maximum serum lipid lowering effect on cholesterol or trigly... |
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Anti-inflammatory activity of 2,3-dihydrophthalazine-1,4-diones in CF1 mice.
Int. J. Tissue React. 18(2-3) , 47-55, (1996) 2,3-Dihydrophthalazine-1,4-diones were observed to be potent anti-inflammatory agents as well as capable of protecting against endotoxin shock in mice at 8 mg/kg i.p. These agents blocked both locally- and centrally-induced pain at 8 mg/kg i.p. In part they a... |
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The anti-neoplastic activity of 2,3-dihydrophthalazine-1,4-dione and N-butyl-2,3-dihydrophthalazine-1,4-dione in human and murine tumor cells.
Anticancer Drugs 3(1) , 55-62, (1992) 2,3-Dihydrophthalazine-1,4-dione derivatives demonstrated potent cytotoxicity against the growth of murine leukemia cells and human single cell suspension, i.e. Tmolt3 leukemia and HeLa-S3, as well as colon adenocarcinoma and KB nasopharynx. However, only sel... |
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Differences in the reactivity of phthalic hydrazide and luminol with hydroxyl radicals.
Free Radic. Res. 30(1) , 45-57, (1999) The reactivity of 5-amino-2,3-dihydro-phthalazine-1,4-dione (luminol) and phthalic hydrazide with hydroxyl radicals was studied. HO*-radicals were generated by the Fenton reaction as well as by water radiolysis. Both luminol and phthalic hydrazide react with ... |
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Disposition of the hypolipidaemic agent, 2,3-dihydrophthalazine-1,4-dione, in Sprague Dawley rats.
J. Pharm. Pharmacol. 41(6) , 394-7, (1989) The disposition of [14C]2,3-dihydrophthalazine-1,4-dione, a potent hypolipidaemic agent, has been determined after both intravenous and oral administration. Both the routes of administration afforded multi-exponential disposition with an estimated t1/2 of app... |