ACTH (4-10)
ACTH (4-10) structure
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Common Name | ACTH (4-10) | ||
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| CAS Number | 4037-01-8 | Molecular Weight | 962.09 | |
| Density | 1.48g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C44H59N13O10S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Ligand-dependent activation of the melanocortin 5 receptor: cAMP production and ryanodine receptor-dependent elevations of [Ca(2+)](I).
Biochem. Biophys. Res. Commun. 290 , 844-850, (2002) The melanocortins are involved in the regulation of various cognitive and physiological processes such as learning, feeding, immune suppression, pigmentation, and sebum production. Five melanocortin receptors have been identified, of which the melanocortin 5 ... |
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Sniffing neuropeptides: a transnasal approach to the human brain.
Nat. Neurosci. 5(6) , 514-6, (2002)
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The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans.
J. Clin. Endocrinol. Metab. 86(3) , 1144-8, (2001) The control of body fat is a prominent factor in human health. Animal studies have indicated a homeostatic central nervous system regulation of body fat with particular involvement of the melanocortin receptor pathway. This study provides evidence for a simil... |
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Advanced glycation end products modulate the maturation and function of peripheral blood dendritic cells.
Diabetes 53(6) , 1452-8, (2004) Advanced glycation end products (AGEs), a complex and heterogeneous group of posttranslational modifications of proteins in vivo, have been widely studied for their involvement in diabetic complications; these complications are largely vascular and accompanie... |
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Intranasal application of the melanocortin 4 receptor agonist MSH/ACTH(4-10) in humans causes lipolysis in white adipose tissue.
Int. J. Obes. 36(5) , 703-8, (2012) The melanocortin system has a highly significant role in the hypothalamic regulation of body weight and energy expenditure. In animals, intracerebroventricular infusion of melanocortin receptor 4 (MCR-4) agonists increases basal metabolic rate through activat... |
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Overweight humans are resistant to the weight-reducing effects of melanocortin4-10.
J. Clin. Endocrinol. Metab. 91(2) , 522-5, (2006) By enhancing energy expenditure and suppressing appetite, melanocortin peptides derived from proopiomelanocortin play a primary role in the hypothalamic regulation of body weight. In a recent study in normal-weight adults, the 6-wk intranasal administration o... |
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Event-related brain potentials and working memory function in healthy humans after single-dose and prolonged intranasal administration of adrenocorticotropin 4-10 and desacetyl-alpha-melanocyte stimulating hormone.
J. Clin. Psychopharmacol. 20(4) , 445-54, (2000) Neuropeptides of the adrenocorticotropin/melanocorticotropin (ACTH/MSH) family are most potent modulators of cognitive function. Their neurobehavioral activity is principally encoded in the 4-10 fragment of the ACTH/MSH molecule; in humans, it has been shown ... |
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Brain potentials and attention after acute and subchronic intranasal administration ofACTH 4-10 and desacetyl-alpha-MSH in humans.
Neuroendocrinology 70(1) , 63-72, (1999) Neuropeptides related to adrenocorticotropin (ACTH) are potent regulators of neurobehavioral functions. In humans, ACTH and its behaviorally active fragment ACTH 4-10 have been consistently found to diminish event-related brain potential (ERP) signs of focuss... |
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Towards the therapeutic use of intranasal neuropeptide administration in metabolic and cognitive disorders
Regul. Pept. 149(1-3) , 79-83, (2008) The nose provides an effective way for delivering neuropeptides to the central nervous system, bypassing the blood-brain barrier and avoiding systemic side effects. Thereby intranasal neuropeptide administration enables the modulation of central nervous signa... |
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Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.
Brain Res. 1117(1) , 54-60, (2006) The heptapeptide Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is an analog of the adrenocorticotropin fragment (4-10) which after intranasal application has profound effects on learning and exerts marked neuroprotective activities. Here, we found that a single applica... |