H-Gly-Pro-Arg-Pro-NH2 acetate salt
H-Gly-Pro-Arg-Pro-NH2 acetate salt structure
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Common Name | H-Gly-Pro-Arg-Pro-NH2 acetate salt | ||
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| CAS Number | 126047-75-4 | Molecular Weight | 424.49800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H32N8O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion.
Protein Sci. 1(12) , 1719-20, (1992)
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The benefit-to-risk profile of melagatran is superior to that of hirudin in a rabbit arterial thrombosis prevention and bleeding model.
J. Thromb. Haemost. 1(3) , 587-94, (2003) Although hirudin is better than heparin at preventing recurrent ischemia in patients with unstable angina, hirudin produces more bleeding. The purpose of this study was to use a rabbit arterial thrombosis prevention and ear bleeding model to determine whether... |
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Role of the Src family kinase Lyn in TxA2 production, adenosine diphosphate secretion, Akt phosphorylation, and irreversible aggregation in platelets stimulated with gamma-thrombin.
.PubMed ID Members of the Src family of kinases are abundant in platelets. Although their localization is known, their role(s) in platelet function are not well understood. Lyn is a Src-family kinase that participates in signal transduction pathways elicited by collagen... |
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Molecular basis for the susceptibility of fibrin-bound thrombin to inactivation by heparin cofactor ii in the presence of dermatan sulfate but not heparin.
J. Biol. Chem. 276(24) , 20959-65, (2001) Although fibrin-bound thrombin is resistant to inactivation by heparin.antithrombin and heparin.heparin cofactor II complexes, indirect studies in plasma systems suggest that the dermatan sulfate.heparin cofactor II complex can inhibit fibrin-bound thrombin. ... |
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The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.
Proc. Natl. Acad. Sci. U. S. A. 94(14) , 7176-81, (1997) After vascular injury, a cascade of serine protease activations leads to the conversion of the soluble fibrinogen molecule into fibrin. The fibrin monomers then polymerize spontaneously and noncovalently to form a fibrin gel. The primary interaction of this p... |
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Amino acids and peptides. XVI. Synthesis of N-terminal tetrapeptide analogs of fibrin alpha-chain and their inhibitory effects on fibrinogen/thrombin clotting.
Chem. Pharm. Bull. 40 , 3253, (1992) N-Terminal tetrapeptide analogs of fibrin alpha-chain were synthesized by the solution method using a new active ester, the ester of the oxime of p-nitroacetophenone, and by the solid-phase method. Their inhibitory effects on fibrinogen/thrombin clotting were... |