RS-1
RS-1 structure
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Common Name | RS-1 | ||
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| CAS Number | 312756-74-4 | Molecular Weight | 524.22600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H16Br2N2O3S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency.
Nat. Commun. 7 , 10548, (2016) Zinc-finger nuclease, transcription activator-like effector nuclease and CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated protein 9) are becoming major tools for genome editing. Importantly, knock-in in several non-ro... |
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Nuclear domain 'knock-in' screen for the evaluation and identification of small molecule enhancers of CRISPR-based genome editing.
Nucleic Acids Res. 43(19) , 9379-92, (2015) CRISPR is a genome-editing platform that makes use of the bacterially-derived endonuclease Cas9 to introduce DNA double-strand breaks at precise locations in the genome using complementary guide RNAs. We developed a nuclear domain knock-in screen, whereby the... |
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A chemical compound that stimulates the human homologous recombination protein RAD51.
Proc. Natl. Acad. Sci. U. S. A. 105 , 15848-15853, (2008) RAD51 and other members of the RecA family of strand exchange proteins assemble on ssDNA to form presynaptic filaments, which carry out the central steps of homologous recombination. A microplate-based assay was developed for high-throughput measurement of hR... |