CGP77675
CGP77675 structure
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Common Name | CGP77675 | ||
|---|---|---|---|---|
| CAS Number | 234772-64-6 | Molecular Weight | 443.54100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H29N5O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.
PLoS ONE 4 , e4449, (2009) Cilengitide is a high-affinity cyclic pentapeptdic alphaV integrin antagonist previously reported to suppress angiogenesis by inducing anoikis of endothelial cells adhering through alphaVbeta3/alphaVbeta5 integrins. Angiogenic endothelial cells express multip... |
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Mechanisms involved in PGE2-induced transactivation of the epidermal growth factor receptor in MH1C1 hepatocarcinoma cells.
J. Exp. Clin. Cancer Res 31 , 72, (2013) It is important to understand the mechanisms by which the cells integrate signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) receptor (EGFR) in the pathophysiology of hepatocarcinomas. Data also suggest a role ... |
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