Chondroitin sulfate sodium salt

Chondroitin sulfate sodium salt Structure
Chondroitin sulfate sodium salt structure
Common Name Chondroitin sulfate sodium salt
CAS Number 9082-07-9 Molecular Weight 1526.03000
Density 1.94g/cm3 Boiling Point N/A
Molecular Formula C42H57N3Na6O43S3 Melting Point N/A
MSDS Chinese USA Flash Point N/A

In vitro reconstitution of complexes between pro-matrix metalloproteinase-9 and the proteoglycans serglycin and versican.

FEBS J. 280(12) , 2870-87, (2013)

Previously, we have shown that a proportion of the matrix metalloproteinase-9 (MMP-9) synthesized by the macrophage cell line THP-1 binds to a chondroitin sulfate proteoglycan (CSPG) core protein to form a reduction-sensitive heteromer. It was also shown that...

Intradiscal application of rhBMP-7 does not induce regeneration in a canine model of spontaneous intervertebral disc degeneration.

Arthritis. Res. Ther. 17 , 137, (2015)

Strategies for biological repair and regeneration of the intervertebral disc (IVD) by cell and tissue engineering are promising, but few have made it into a clinical setting. Recombinant human bone morphogenetic protein 7 (rhBMP-7) has been shown to stimulate...

Efficacy and safety of antifungal additives in Optisol-GS corneal storage medium.

JAMA Ophthalmol. 132(7) , 832-7, (2014)

Optisol-GS, the most common corneal storage medium in the United States, contains antibacterial but no antifungal supplementation. Most postkeratoplasty endophthalmitis and keratitis cases are now of a fungal origin.To assess the efficacy and safety of vorico...

The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs.

Eur. Cell. Mater. 30 , 132-46; discussion 146-7, (2015)

During intervertebral disc (IVD) maturation, the main cell type shifts from notochordal cells (NCs) to chondrocyte-like cells (CLCs). NCs secrete factors with regenerative potential, making them an interesting focus for regenerative treatments. During initial...

A Structurally and Functionally Biomimetic Biphasic Scaffold for Intervertebral Disc Tissue Engineering.

PLoS ONE 10(6) , e0131827, (2015)

Tissue engineering offers high hopes for the treatment of intervertebral disc (IVD) degeneration. Whereas scaffolds of the disc nucleus and annulus have been extensively studied, a truly biomimetic and mechanically functional biphasic scaffold using naturally...

Chondroitin Sulfate is the Primary Receptor for a Peptide-Modified AAV That Targets Brain Vascular Endothelium In Vivo.

Mol. Ther. Nucleic Acids 3 , e202, (2014)

Recently, we described a peptide-modified AAV2 vector (AAV-GMN) containing a capsid-displayed peptide that directs in vivo brain vascular targeting and transduction when delivered intravenously. In this study, we sought to identify the receptor that mediates ...

Trypan blue vital dye staining vs TUNEL technique to detect corneal endothelium toxic effects.

JAMA Ophthalmol. 132(12) , 1491, (2014)

Ultrastructural and biochemical characterization of mechanically adaptable collagenous structures in the edible sea urchin Paracentrotus lividus.

Zoology (Jena.) 118 , 147-60, (2015)

The viscoelastic properties of vertebrate connective tissues rarely undergo significant changes within physiological timescales, the only major exception being the reversible destiffening of the mammalian uterine cervix at the end of pregnancy. In contrast to...

Solute transport across the articular surface of injured cartilage.

Arch. Biochem. Biophys. 535(2) , 241-7, (2013)

Solute transport through extracellular matrix (ECM) is important to physiology and contrast agent-based clinical imaging of articular cartilage. Mechanical injury is likely to have important effects on solute transport since it involves alteration of ECM stru...

Effect of hydration state and storage media on corneal biomechanical response from in vitro inflation tests.

J. Refract. Surg. 29(7) , 490-7, (2013)

To evaluate corneal deformation with varying intraocular pressure and the dependency of the biomechanical response on the corneal hydration state, modulated by the storage solutions or postmortem period.Thirty fresh enucleated porcine eyes were used for in vi...