Nociceptin(Orphanin FQ)
Nociceptin(Orphanin FQ) structure
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Common Name | Nociceptin(Orphanin FQ) | ||
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| CAS Number | 170713-75-4 | Molecular Weight | 1809.037 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C79H129N27O22 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Pharmacological characterization of the nociceptin receptor, ORL1. Insight from the inward rectifier activation in the periaqueductal gray.
J. Biomed. Sci. 7 , 232, (2000) A novel opioid receptor-like orphan receptor (ORL1) was cloned and identified to be homologous to classical opioid receptors but insensitive to traditional opioids. A heptadecapeptide, termed orphanin FQ or nociceptin (OFQ/N), was identified as its endogenous... |
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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Nature 377 , 532-535, (1995) The ORL1 receptor, an orphan receptor whose human and murine complementary DNAs have recently been characterized, structurally resembles opioid receptors and is negatively coupled with adenylate cyclase. ORL1 transcripts are particularly abundant in the centr... |
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Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.
Science 270 , 792-794, (1995) A heptadecapeptide was identified and purified from porcine brain tissue as a ligand for an orphan heterotrimeric GTP-binding protein (G protein)-coupled receptor (LC132) that is similar in sequence to opioid receptors. This peptide, orphanin FQ, has a primar... |
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Orphanin FQ/nociceptin receptor binding studies.
Peptides 21 , 949, (2000) A review of the binding studies performed on the receptor (ORL) for Orphanin FQ/Nociceptin is presented. Binding studies have been conducted using a variety of receptor sources: cell lines expressing the cloned receptor, cell lines endogenously expressing the... |