isosorbide 2-mononitrate
isosorbide 2-mononitrate structure
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Common Name | isosorbide 2-mononitrate | ||
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| CAS Number | 16106-20-0 | Molecular Weight | 191.13900 | |
| Density | 1.56g/cm3 | Boiling Point | 364.5ºC at 760mmHg | |
| Molecular Formula | C6H9NO6 | Melting Point | >51.5°C | |
| MSDS | N/A | Flash Point | 174.2ºC | |
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Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on isolated dog aorta: vascular relaxation and increase in cyclic GMP.
Arch. Int. Pharmacodyn. Ther. 312 , 104-9, (1991) The effects of isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) on vascular smooth muscle tone and on cyclic nucleotide levels were studied in isolated dog aorta. The effects of the mononitrates were compared with that of the relative... |
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Pharmacokinetic/pharmacodynamic relationship of the duration of vasodilating action of organic mononitrates in rats.
J. Pharmacol. Exp. Ther. 261(2) , 692-700, (1992) Conflicting information existed regarding the relevance of pharmacokinetics in relation to the duration of action of organic nitrates. We examined this question using three geometric isomers of organic mononitrates, L-isoidide mononitrate, isosorbide-2-mononi... |
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[Study of the bioequivalence of a new isosorbide dinitrate tablet formulation compared with the standard preparation].
Arzneimittelforschung 47(6) , 719-26, (1997) An investigation in the bioequivalence of a new tablet formulation with 5 mg isosorbide dinitrate (CAS 87-33-2, ISDN 5 von ct) was performed in a two-way cross-over study with 18 subjects. The relative bioavailability with respect to a reference preparation f... |
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Concentrations of isosorbide dinitrate, isosorbide-2-mononitrate and isosorbide-5-mononitrate in human vascular and muscle tissue under steady-state conditions.
Eur. J. Clin. Pharmacol. 38(2) , 145-7, (1990) The concentrations of isosorbide dinitrate (ISDN), isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) were determined in plasma (PL), saphenous vein wall (SV) and pectoral muscle (PM) from 8 patients undergoing coronary bypass surgery. ... |
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A pharmacokinetic model for isosorbidedinitrate, isosorbide-2-mononitrate, and isosorbide-5-mononitrate.
Drug Metab. Dispos. 18(4) , 429-34, (1990) A pharmacokinetic model is proposed to describe the plasma levels of isosorbidedinitrate (ISDN) and its two pharmacologically active metabolites, isosorbide-2-mononitrate (IS-2MN) and isosorbide-5-mononitrate (IS-5MN), following the oral administration of sev... |
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Pharmacokinetics of stereomeric 1,4:3,6-dianhydrohexitol mononitrates in rats.
Pharm. Res. 10(1) , 22-7, (1993) The pharmacokinetics and urinary recoveries of four isomeric mononitrates, L-isoidide mononitrate (L-IIMN), isosorbide-2-mononitrate (IS-2-MN), isomannide mononitrate (IMMN), and isosorbide-5-mononitrate (IS-5-MN), were investigated at an intravenous dose of ... |
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Influence of standard and nicotine-reduced cigarette smoke on plasma concentrations of isosorbide dinitrate and its metabolites in rats.
J. Pharm. Pharmacol. 43(11) , 811-2, (1991) Rats dosed orally with isosorbide dinitrate (1 mg kg-1) were exposed to smoke from standard and nicotine-reduced cigarettes for 8 min using a smoking machine. Plasma concentrations of isosorbide dinitrate and 5-isosorbide mononitrate, one of its major metabol... |
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Effects of isosorbide-5-mononitrate and isosorbide-2-mononitrate on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of the guinea-pig and dog.
J. Pharm. Pharmacol. 44(8) , 663-6, (1992) Isosorbide-5-mononitrate and isosorbide-2-mononitrate, the metabolites of isosorbide dinitrate, were studied for their effects on the contractile and electrical activity and on the content of cyclic nucleotides in isolated heart muscles of guinea-pig and dog.... |
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Differences between nitrates: role of isosorbide 2-mononitrate.
J. Cardiovasc. Med. (Hagerstown.) 11(7) , 486-92, (2010) Nitrates are used in the treatment of coronary heart disease and heart failure. The major drawback of their therapeutic use is the rapid development of tolerance.To investigate the effect of different nitrates on isolated rabbit hearts and aortic strips and t... |
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Influence of emotional stress on pharmacokinetics of isosorbide dinitrate intraperitoneally administered to rats.
Acta Med. Okayama 44(1) , 51-3, (1990) The plasma level of isosorbide dinitrate intraperitoneally administered to rats stressed by foot-shock was almost the same as that in non-stressed control rats. However, levels of its metabolites, 5-isosorbide mononitrate and 2-isosorbide mononitrate, were lo... |