Gamma-Tocotrienol
Gamma-Tocotrienol structure
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Common Name | Gamma-Tocotrienol | ||
|---|---|---|---|---|
| CAS Number | 14101-61-2 | Molecular Weight | 410.632 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 530.8±49.0 °C at 760 mmHg | |
| Molecular Formula | C28H42O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 218.4±24.1 °C | |
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Plastochromanol-8: fifty years of research.
Phytochemistry 108 , 9-16, (2014) Plastochromanol-8 (PC-8) is an antioxidant that, together with tocopherols and tocotrienols, belongs to the group of tocochromanols. Plastochromanol-8 has been found to occur in several plant species, including mosses, and lichens. PC-8 is found in seeds, lea... |
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Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.
Cell Prolif. 46(2) , 203-13, (2013) Tocotrienols and tocopherols are members of the vitamin E family, with similar structures; however, only tocotrienols have been reported to achieve potent anti-cancer effects. The study described here has evaluated anti-cancer activity of vitamin E to elucida... |
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Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.
J. Nutr. Sci. Vitaminol. 57(5) , 326-32, (2011) We previously found that 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (_CEHC), a metabolite of the vitamin E isoforms _-tocopherol or _-tocotrienol, accumulated in the rat small intestine. The aim of this study was to evaluate tissue distribution of vi... |
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δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells.
Microsc. Microanal. 18(3) , 462-9, (2012) Tocotrienols are isomers of the vitamin E family, which have been reported to exert cytotoxic effects in various cancer cells. Although there have been some reports on the effects of tocotrienols in leukemic cells, ultrastructural evidence of tocotrienol-indu... |
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Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells.
Free Radic. Res. 46(2) , 184-93, (2012) It is well known that reactive oxygen species (ROS) attack several living tissues and increase the risk of development and progression of serious diseases. In neuronal level, ROS induce cell death in concentration-dependent fashion. However, little is known a... |
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Enhancement of intestinal permeability utilizing solid lipid nanoparticles increases γ-tocotrienol oral bioavailability.
Lipids 47(5) , 461-9, (2012) γ-Tocotrienol (γ-T3), a member of the vitamin E family, has been reported to possess an anticancer activity. γ-T3 is a lipophilic compound with low oral bioavailability. Previous studies showed that γ-T3 has low intestinal permeability. Thus, we have hypothes... |
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Mobilization of progenitor cells into peripheral blood by gamma-tocotrienol: a promising radiation countermeasure.
Int. Immunopharmacol. 15(3) , 557-64, (2013) Gamma-tocotrienol (GT3), a vitamin E isoform, is shown to induce high levels of granulocyte colony stimulating factor (G-CSF) in mice. G-CSF is a key cytokine used for stimulation of hematopoiesis, and mobilization of hematopoietic stem and progenitor cells i... |
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Antidiabetic effects of a standardized Egyptian rice bran extract.
Phytother Res. 27(2) , 264-71, (2013) An extract was prepared from Egyptian stabilized rice bran and standardized to contain 2% γ-oryzanol in addition to its content of other bioactives, notably tocotrienol and policosanol. The standardized extract was found to have a concentration-dependent effe... |
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Involvement of de novo ceramide synthesis in gamma-tocopherol and gamma-tocotrienol-induced apoptosis in human breast cancer cells.
Mol. Nutr. Food. Res. 56(12) , 1803-11, (2012) This study further examines mechanisms involved in the pro-apoptotic action of gamma-tocopherol (γT) and gamma-tocotrienol (γT3) in human breast cancer cell lines.γT upregulates phospho-JNK (pJNK), CCAAT/enhancer-binding protein homologous protein (CHOP), and... |
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Function of plastochromanol and other biological prenyllipids in the inhibition of lipid peroxidation-A comparative study in model systems.
Biochim. Biophys. Acta 1828(2) , 233-40, (2013) Lipid peroxidation is an oxidation reaction leading to the generation of lipid hydroperoxides. Here we present comparative data on the inhibition of lipid peroxidation by a variety of biological prenyllipids in liposomes prepared from natural lipid membranes.... |