3,3'-Diethyloxacarbocyanine iodide
3,3'-Diethyloxacarbocyanine iodide structure
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Common Name | 3,3'-Diethyloxacarbocyanine iodide | ||
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| CAS Number | 905-96-4 | Molecular Weight | 460.31 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H21IN2O2 | Melting Point | 278ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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TLR signaling modulates side effects of anticancer therapy in the small intestine.
J. Immunol. 194(4) , 1983-95, (2015) Intestinal mucositis represents the most common complication of intensive chemotherapy, which has a severe adverse impact on quality of life of cancer patients. However, the precise pathophysiology remains to be clarified, and there is so far no successful th... |
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Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington's disease R6/2 model.
Sci. Rep. 5 , 16887, (2015) Mutant huntingtin (mHtt) aggregation in the nucleus is the most readily apparent phenotype and cause of neuronal death in Huntington's disease (HD). Inhibiting mHtt aggregation reduces cell death in the brain and is thus a promising therapeutic approach. The ... |
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Structure-activity relationship of cyanine tau aggregation inhibitors.
J. Med. Chem. 52 , 3539-47, (2009) A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine bridge length, and the nature of meso- and N-substituents.... |
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Mitochondrial Apoptotic Pathway Is Activated by H2O2-Mediated Oxidative Stress in BmN-SWU1 Cells from Bombyx mori Ovary.
PLoS ONE 10 , e0134694, (2015) Apoptosis is a known regulator of morphogenetic events. In mammals, the critical role of oxidative stress-induced apoptosis has been well-studied; however, in insects the role of oxidative stress in apoptosis is not clear. In a previous study, we showed that ... |
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Dissimilar expression of multidrug resistance mdr1 and bcrp by the replication of hepatitis C virus: role of the nonstructural 5A protein.
J. Viral Hepat. 20(4) , e127-30, (2013) Multidrug resistance associated with the overexpression of ATP-dependent binding cassette (ABC) proteins is widely accepted as an important cause of treatment failure in patients with neoplastic or infectious diseases. Some of them play also a pivotal role in... |
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Poloxamines display a multiple inhibitory activity of ATP-binding cassette (ABC) transporters in cancer cell lines.
Mol. Pharm. 8(4) , 1152-64, (2011) Primary hepatocellular carcinoma is the third most common fatal cancer worldwide with more than 500,000 annual deaths. Approximately 40% of the patients with HCC showed tumoral overexpression of transmembrane proteins belonging to the ATP-binding cassette pro... |
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Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human
Eur. J. Pharm. Sci. 35(1-2) , 114-26, (2008) The large interspecies differences of hepatobiliary transport present a challenge for the allometric prediction of human biliary excretion for drug candidates primarily cleared via hepatobiliary secretion. In the present study, we determined the metabolic sta... |
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The novel BCR-ABL and FLT3 inhibitor ponatinib is a potent inhibitor of the MDR-associated ATP-binding cassette transporter ABCG2.
Mol. Cancer Ther. 11(9) , 2033-44, (2012) Ponatinib is a novel tyrosine kinase inhibitor with potent activity against BCR-ABL with mutations, including T315I, and also against fms-like tyrosine kinase 3. We tested interactions between ponatinib at pharmacologically relevant concentrations of 50 to 20... |
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Analysis of P-glycoprotein-mediated membrane transport in human peripheral blood lymphocytes using the UIC2 shift assay.
Cytometry. A 53(2) , 67-78, (2003) During transport-associated adenosine triphosphate hydrolysis, P-glycoprotein (Pgp) undergoes conformation transitions detected by UIC2, a functional anti-Pgp monoclonal antibody. A newly developed UIC2 shift assay is based on increased UIC2 reactivity in the... |
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Inhibition of mitochondrial and Paracoccus denitrificans NADH-ubiquinone reductase by oxacarbocyanine dyes. A structure-activity study.
Biochem. Pharmacol. 45(10) , 2115-22, (1993) In this study, we determined that three structurally related oxacarbocyanine dyes, 3,3'-diethyloxacarbocyanine (DiOC2(3)), 3,3'-dipentyloxacarbocyanine (DiOC5(3)), and 3,3'-dihexyloxacarbocyanine (DiOC6(3)), and one oxadicarbocyanine, 3,3'-diethyloxadicarbocy... |