Berberine hydrochloride
Berberine hydrochloride structure
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Common Name | Berberine hydrochloride | ||
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| CAS Number | 633-65-8 | Molecular Weight | 372.822 | |
| Density | 1.654g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H18ClNO4 | Melting Point | 200ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Berberine blocks the relapse of Clostridium difficile infection in C57BL/6 mice after standard vancomycin treatment.
Antimicrob. Agents Chemother. 59 , 3726-35, (2015) Vancomycin is a preferred antibiotic for treating Clostridium difficile infection (CDI) and has been associated with a rate of recurrence of CDI of as high as 20% in treated patients. Recent studies have suggested that berberine, an alternative medical therap... |
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Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli.
Antimicrob. Agents Chemother. 52 , 3052-60, (2008) Active efflux of antimicrobial agents is one of the most important adapted strategies that bacteria use to defend against antimicrobial factors that are present in their environment. The NorM protein of Neisseria gonorrhoeae and the YdhE protein of Escherichi... |
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Synergistic topical application of salt-processed Phellodendron amurense and Sanguisorba officinalis Linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin E and pro-inflammatory cytokines in NC/Nga mice.
Mol. Med. Report. 12 , 7657-64, (2015) Atopic dermatitis is a chronic inflammatory skin disease, and salt-processed Phellodendron amurense (CPE) and Sanguisorba officinalis Linne (SOE) are widely used as anti-inflammatory agents in Asia. Therefore, the present study investigated the efficacy of CP... |
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Berberine induces senescence of human glioblastoma cells by downregulating the EGFR-MEK-ERK signaling pathway.
Mol. Cancer Ther. 14(2) , 355-63, (2015) Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor and has a poor prognosis. We, here, report a potent antitumor effect of berberine, an isoquinoline alkaloid, on GBM. Berberine was found to have an IC50 that is much lower than tem... |
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Berberine inhibits the proliferation of human uterine leiomyoma cells.
Fertil. Steril. 103(4) , 1098-106, (2015) To determine whether berberine (BBR), a naturally occurring plant-derived alkaloid, inhibits the proliferation of human uterine leiomyoma (UtLM) cells.Laboratory research.Laboratory.UtLM and normal human uterine smooth muscle (UtSMC) cell lines.Treatment with... |
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Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters.
J. Transl. Med. 13 , 278, (2015) Berberine (BBR), as a new medicine for hyperlipidemia, can reduce the blood lipids in patients. Mechanistic studies have shown that BBR activates the extracellular-signal regulated kinase pathway by stabilizing low-density-lipoprotein receptor mRNA. However, ... |
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Membrane transporters in drug development.
Nat. Rev. Drug Discov. 9 , 215-236, (2010) Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key questions for drug development, including which transporters are clinically important in drug absorption and disposition, ... |
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Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Eur. J. Med. Chem. 45 , 4813-26, (2010) In this study, we have explored the structure activity relationships of substrates of two major, promiscuous, multidrug transporters of an opportunistic human pathogen Candida albicans namely, CaCdr1p and CaMdr1p. To differentiate between substrates and non-s... |
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Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones
Eur. J. Med. Chem. 45 , 2447-52, (2010) A convenient, fast and high yielding method for the preparation of 7-methoxyisoflavanone and 2,3-diarylchromanones has been developed by the condensation of benzyl-2-hydroxy-4-alkoxyphenylketone with arylaldehyde/paraformaldehyde in presence of diethylamine, ... |
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Discovery of estrogen receptor α modulators from natural compounds in Si-Wu-Tang series decoctions using estrogen-responsive MCF-7 breast cancer cells.
Bioorg. Med. Chem. Lett. 22 , 154-63, (2012) The binding between the estrogen receptor α (ER-α) and a variety of compounds in traditional Chinese formulae, Si-Wu-Tang (SWT) series decoctions, was studied using a stably-transfected human breast cancer cell line (MVLN). In 38 compounds tested from SWT ser... |