Disodium 2'-deoxy-5'-O-phosphonatocytidine
Disodium 2'-deoxy-5'-O-phosphonatocytidine structure
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Common Name | Disodium 2'-deoxy-5'-O-phosphonatocytidine | ||
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| CAS Number | 13085-50-2 | Molecular Weight | 351.161 | |
| Density | N/A | Boiling Point | 633.8ºC at 760mmHg | |
| Molecular Formula | C9H12N3Na2O7P | Melting Point | 179-180ºC | |
| MSDS | USA | Flash Point | 337.1ºC | |
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Nucleoside monophosphate kinases: structure, mechanism, and substrate specificity.
Adv. Enzymol. Relat. Areas Mol. Biol. 73 , 103-134, (1999) The catalytic mechanisms of adenylate kinase, guanylate kinase, uridylate kinase, and cytidylate kinase are reviewed in terms of kinetic and structural information that has been obtained in recent years. All four kinases share a highly related tertiary struct... |
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Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by Human UMP/CMP Kinase Is Differentially Regulated by ATP and Magnesium.
Mol. Pharmacol. 67 , 806-814, (2004) Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticanc... |
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Nucleotide binding to human UMP-CMP kinase using fluorescent derivatives -- a screening based on affinity for the UMP-CMP binding site.
FEBS J. 274 , 3704-3714, (2007) Methylanthraniloyl derivatives of ATP and CDP were used in vitro as fluorescent probes for the donor-binding and acceptor-binding sites of human UMP-CMP kinase, a nucleoside salvage pathway kinase. Like all NMP kinases, UMP-CMP kinase binds the phosphodonor, ... |
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Molecular modeling and dynamics studies of cytidylate kinase from Mycobacterium tuberculosis H37Rv.
J. Mol. Model. 14 , 427-434, (2008) Bacterial cytidylate kinase or cytidine monophosphate kinase (CMP kinase) catalyses the phosphoryl transfer from ATP to CMP and dCMP, resulting in the formation nucleoside diphosphates. In eukaryotes, CMP/UMP kinase catalyses the conversion of UMP and CMP to,... |