Exametazime
Exametazime structure
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Common Name | Exametazime | ||
|---|---|---|---|---|
| CAS Number | 105613-48-7 | Molecular Weight | 272.38700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H28N4O2 | Melting Point | 128-130° | |
| MSDS | N/A | Flash Point | N/A | |
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An efficient HPLC method for the analysis of isomeric purity of technetium-99m-exametazime and identity confirmation using LC-MS.
J. Pharm. Biomed. Anal. 32(4-5) , 679-85, (2003) 99mTc-exametazime (99mTc-d,l-HMPAO, 99mTc-d,l-hexamethylpropyleneamine oxime) is a neutral rather unstable complex of short-lived 99mTc (t(1/2)=6 h) with the d,l-isomer (mixture of D,D- and L,L-isomers) of a bis-amine bis-oxime tetraligand. It is widely used ... |
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Nicotinic alpha4beta2 receptor binding in dementia with Lewy bodies using 123I-5IA-85380 SPECT demonstrates a link between occipital changes and visual hallucinations.
Neuroimage 40(3) , 1056-63, (2008) To investigate in vivo differences in the distribution of alpha4beta2 subtypes of nAChR using the ligand (123)I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) in DLB and similarly aged controls.... |
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Leukocyte SPECT/CT for detecting infection of left-ventricular-assist devices: preliminary results.
J. Nucl. Med. 51(7) , 1044-8, (2010) We report our experience with using integrated molecular and anatomic hybrid imaging to assess infection in patients who have a left-ventricular-assist device (LVAD).Thirteen (99m)Tc-exametazime-leukocyte planar and SPECT/CT scans were obtained for 8 consecut... |
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Chiral ligand-exchange chromatography for diastereo-enantio separation of exametazime.
J. Pharm. Biomed. Anal. 32(6) , 1159-66, (2003) The diastereo-enantio separation of isomeric mixtures of exametazime (HM-PAO) by liquid chromatography is described using an achiral sorbent (RP-18). A chiral eluent with the initial complex of Cu(II) and the optically active selector N,N-dimethyl-l-phenylala... |
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Consensus development for producing diagnostic procedure guidelines: SPECT brain perfusion imaging with exametazime.
J. Nucl. Med. 35(12) , 2003-10, (1994) A method for developing diagnostic practice guidelines is presented in which a team of experts used a semiquantitative scoring system to reach consensus on a standard procedure for SPECT cerebral perfusion imaging.An expert panel generated a list of elements ... |
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Multivariate spatial covariance analysis of 99mTc-exametazime SPECT images in dementia with Lewy bodies and Alzheimer's disease: utility in differential diagnosis.
J. Cereb. Blood Flow Metab. 33(4) , 612-8, (2013) We examined (99m)Tc-exametazime brain blood flow single-photon emission computed tomography (SPECT) images using a spatial covariance analysis (SCA) approach to assess its diagnostic value in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's dis... |
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Preparation and storage of single-dose portions of exametazime: effects on radiochemical purity after labeling.
Am. J. Hosp. Pharm. 49(8) , 1950-4, (1992) The effect of exametazime concentration, storage time, and the volume of the radiolabeling compound on the radiochemical purity of labeled exametazime doses was studied. Exametazime cold unit doses (CUDs) of 0.50, 0.33, 0.25, 0.17, and 0.13 mg/mL were prepare... |
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Alterations in nicotinic α4β2 receptor binding in vascular dementia using ¹²³I-5IA-85380 SPECT: comparison with regional cerebral blood flow.
Neurobiol. Aging 32(2) , 293-301, (2011) To investigate differences in distribution of α4β2 subtypes of nicotinic acetylcholine receptors (nAChRs) using the ligand ¹²³I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) and single photon emission computed tomography (SPECT) in subjects with va... |
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Chiral ligand-exchange chromatography as the screening method for proposed modifications in exametazime synthesis to enhance diastereoselectivity.
J. Pharm. Biomed. Anal. 34(2) , 285-93, (2004) 99M Tc (V)-d,l-HM-PAO complex is well-known radiopharmaceutical for regional cerebral blood flow imaging. The proposed modifications in exametazime, hexamethylpropyleneamine oxime (HM-PAO) (4,8-diaza-3,6,6,9-tetramethylundecane-2,10-dione bisoxime) synthesis,... |
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Trafficking and homing of systemically administered stem cells: the need for appropriate analysis tools of radionuclide images.
Q. J. Nucl. Med. Mol. Imaging 57(2) , 207-15, (2013) Despite its enormous relevance, homing of hematopoietic stem cells (SCs) remains relatively uncertain due to the limitations of measuring small number of systemically administered cells in the different organs. Despite its high sensitivity, radionuclide detec... |